Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh

Haematology Journal of Bangladesh

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Title Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh
Creator Baqi, Saqi Md. Abdul
Munmun, Umme Kulsum
Khan, Md. Rafiquzzaman
Shah, Md. Salahuddin
Islam, Shafiqul
Rahman, Farzana
Aziz, Md. Abdul
Begum, Masuda
Subject acute myeloid leukaemia
Description Background: Cytogenetic analysis performed at diagnosis is considered to be the most important prognostic factor in AML. Objective: The purpose of this study was to observe the pattern of cytogenetic abnormalities in adult patients with de novo AML. Method: Total fifty-two newly diagnosed de novo AML patients were selected for the study. Six cytogenetic abnormalities including t(8;21), t(15;17), inv(16), BCR-ABL1, FLT3-ITD & NPM1 mutations were detected by Real-Time PCR. Results: In this study, 36 (69.2%) patients showed different cytogenetic abnormalities. The t(15;17) was found to be the most common. t(15;17), t(8;21) and inv(16) were found only in M3, M2 and M4 FAB subtypes, respectively. Significant association was found with increasing age and cytogenetic risk groups. BCR-ABL1 mutation showed significant relation with increased age. FLT3-ITD mutation showed significant association with increased WBC count and inv16 was significantly associated with relatively less bone marrow blast percentage. Conclusion: Cytogenetic study should be performed routinely in all cases of AML for proper diagnosis, prediction of prognosis and implementation of effective therapeutic measures.
Publisher Haematology Society of Bangladesh
Date 2020-06-20
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format text/html
Source Haematology Journal of Bangladesh; Vol. 4 No. 1 (2020); 08-12
Language eng
Rights Copyright (c) 2020 Saqi Md. Abdul Baqi, Umme Kulsum Munmun, Md. Rafiquzzaman Khan, Md. Salahuddin Shah, Shafiqul Islam, Farzana Rahman, Md. Abdul Aziz, Masuda Begum

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