Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh
Haematology Journal of Bangladesh
View Publication Info| Field | Value | |
| Title |
Cytogenetic Pattern in Adult Patients with de novo Acute Myeloid Leukaemia: A Single Centre Study in Bangladesh
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| Creator |
Baqi, Saqi Md. Abdul
Munmun, Umme Kulsum Khan, Md. Rafiquzzaman Shah, Md. Salahuddin Islam, Shafiqul Rahman, Farzana Aziz, Md. Abdul Begum, Masuda |
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| Subject |
acute myeloid leukaemia
cytogenetics |
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| Description |
Background: Cytogenetic analysis performed at diagnosis is considered to be the most important prognostic factor in AML. Objective: The purpose of this study was to observe the pattern of cytogenetic abnormalities in adult patients with de novo AML. Method: Total fifty-two newly diagnosed de novo AML patients were selected for the study. Six cytogenetic abnormalities including t(8;21), t(15;17), inv(16), BCR-ABL1, FLT3-ITD & NPM1 mutations were detected by Real-Time PCR. Results: In this study, 36 (69.2%) patients showed different cytogenetic abnormalities. The t(15;17) was found to be the most common. t(15;17), t(8;21) and inv(16) were found only in M3, M2 and M4 FAB subtypes, respectively. Significant association was found with increasing age and cytogenetic risk groups. BCR-ABL1 mutation showed significant relation with increased age. FLT3-ITD mutation showed significant association with increased WBC count and inv16 was significantly associated with relatively less bone marrow blast percentage. Conclusion: Cytogenetic study should be performed routinely in all cases of AML for proper diagnosis, prediction of prognosis and implementation of effective therapeutic measures.
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| Publisher |
Haematology Society of Bangladesh
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| Date |
2020-06-20
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-Reviewed Article |
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| Format |
text/html
application/pdf |
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| Identifier |
https://journal.hematologybd.org/index.php/haematoljbd/article/view/47
10.37545/haematoljbd202047 |
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| Source |
Haematology Journal of Bangladesh; Vol. 4 No. 1 (2020); 08-12
2707-1405 2523-1219 |
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| Language |
eng
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| Relation |
https://journal.hematologybd.org/index.php/haematoljbd/article/view/47/59
https://journal.hematologybd.org/index.php/haematoljbd/article/view/47/159 |
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| Rights |
Copyright (c) 2020 Saqi Md. Abdul Baqi, Umme Kulsum Munmun, Md. Rafiquzzaman Khan, Md. Salahuddin Shah, Shafiqul Islam, Farzana Rahman, Md. Abdul Aziz, Masuda Begum
https://creativecommons.org/licenses/by-nc/4.0 |
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