Dysbiosis of the gut microbiota in disease

Microbial Ecology in Health and Disease

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Field Value
 
Title Dysbiosis of the gut microbiota in disease
 
Creator Carding, Simon
Verbeke, Kristin
Vipond, Daniel T.
Corfe, Bernard M.
Owen, Lauren
 
Subject colon health; IBD; short chain fatty acids; mental health; gut-brain axix
 
Description There is growing evidence that dysbiosis of the gut microbiota is associated with the pathogenesis of both intestinal and extra-intestinal disorders. Intestinal disorders include inflammatory bowel disease, irritable bowel syndrome (IBS), and coeliac disease, while extra-intestinal disorders include allergy, asthma, metabolic syndrome, cardiovascular disease, and obesity.In many of these conditions, the mechanisms leading to disease development involves the pivotal mutualistic relationship between the colonic microbiota, their metabolic products, and the host immune system. The establishment of a ‘healthy’ relationship early in life appears to be critical to maintaining intestinal homeostasis. Whilst we do not yet have a clear understanding of what constitutes a ‘healthy’ colonic microbiota, a picture is emerging from many recent studies identifying particular bacterial species associated with a healthy microbiota. In particular, the bacterial species residing within the mucus layer of the colon, either through direct contact with host cells, or through indirect communication via bacterial metabolites, may influence whether host cellular homeostasis is maintained or whether inflammatory mechanisms are triggered. In addition to inflammation, there is some evidence that perturbations in the gut microbiota is involved with the development of colorectal cancer. In this case, dysbiosis may not be the most important factor, rather the products of interaction between diet and the microbiome. High-protein diets are thought to result in the production of carcinogenic metabolites from the colonic microbiota that may result in the induction of neoplasia in the colonic epithelium.Ever more sensitive metabolomics methodologies reveal a suite of small molecules produced in the microbiome which mimic or act as neurosignallers or neurotransmitters. Coupled with evidence that probiotic interventions may alter psychological endpoints in both humans and in rodent models, these data suggest that CNS-related co-morbidities frequently associated with GI disease may originate in the intestine as a result of microbial dysbiosis.This review outlines the current evidence showing the extent to which the gut microbiota contributes to the development of disease. Based on evidence to date, we can assess the potential to positively modulate the composition of the colonic microbiota and ameliorate disease activity through bacterial intervention.Keywords: Microbiome; short-chain fatty acids; gut health; colonic metabolome; gut–brain–axis; inflammation(Published: 2 February 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 26191 - http://dx.doi.org/10.3402/mehd.v26.26191This paper is part of the Proceedings from the 2013 ENGIHR Conference in Valencia, Spain. More papers from this supplement can be found at http://www.microbecolhealthdis.net
 
Publisher Microbial Ecology in Health and Disease
 
Contributor ENGIHR
 
Date 2015-02-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/26191
10.3402/mehd.v26.26191
 
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/26191/38229
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26191/38230
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26191/38231
 

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