Approaches to studying and manipulating the enteric microbiome to improve autism symptoms

Microbial Ecology in Health and Disease

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Title Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
 
Creator Frye, Richard E.
Slattery, John
MacFabe, Derrick F.
Allen-Vercoe, Emma
Parker, William
Rodakis, John
Adams, James B.
Krajmalnik-Brown, Rosa
Bolte, Ellen
Kahler, Stephen
Jennings, Jana
James, Jill
Cerniglia, Carl E.
Midtvedt, Tore
 
Subject Autism Spectrum Disorder, Clinical Trials, Clostridia, Consensus, Epigenetics, Fecal Microbial Transplant, Microbiome, Mitochondria, Probiotic, Short Chain Fatty Acids, Vancomycin
 
Description There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms. One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future.Keywords: autism spectrum disorder; clinical trials; Clostridia; fecal microbiota transplantation (FMT); microbiome; mitochondria; probiotic; short chain fatty acids; vancomycin; gastrointestinal(Published: 7 May 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 26878 - http://dx.doi.org/10.3402/mehd.v26.26878
 
Publisher Microbial Ecology in Health and Disease
 
Contributor The Autism Research Program at Arkansas Children’s Hospital Research Institute and the N of One: Autism Research Foundation
 
Date 2015-05-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/26878
10.3402/mehd.v%v.26878
 
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/26878/39925
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26878/39926
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26878/39927
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26878/39928
 
Rights http://creativecommons.org/licenses/by-nc/4.0
 

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