Double-blind controlled randomised study of lactulose and lignin hydrolysed combination in complex therapy of atopic dermatitis

Microbial Ecology in Health and Disease

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Title Double-blind controlled randomised study of lactulose and lignin hydrolysed combination in complex therapy of atopic dermatitis
 
Creator Perlamutrov, Yuri N.
Olhovskaya, Kira B.
Zakirova, Svetlana A.
 
Subject Atopic Dermatitis; Lactofiltrum; Lactulose; Lignin Hydrolysed; Allergic Disease
 
Description Background: Atopic dermatitis (AD) is an immune mediated disease with complex pathogenesis characterised by persistency, frequent exacerbations, and inefficacy of existing therapies. Damaged or weakened intestinal microbiocenosis is considered as an important aetiological factor of AD. The aim of this study was to evaluate the efficacy and safety of medical preparation Lactofiltrum (lactulose and sorbent (lignin hydrolysed)) in comparison with placebo in complex with standard therapy of AD.Methods: Double-blind, placebo controlled, randomised comparative study of effectiveness and safety of 400 mg lactulose and 120 mg lignin hydrolysed combination as a part of standard combined AD treatment, conducted in parallel groups of patients aged 18–60.Results: Comparison of clinical efficacy of Lactofiltrum in combination with the standard treatment has been demonstrated by measuring the following parameters: administration of Lactofiltrum results in 1) distinct clinical improvement in 56.75% of patients, 2) decrease of the mean values of scoring atopic dermatitis (SCORAD) index in 71.94% of patients, 3) elimination of itching in 50% of patients, and 4) life quality improvement for 76.41%. In the placebo group, 1) distinct clinical improvement was observed in 20% of patients, 2) decrease in SCORAD index values observed by 56.98%, 3) itching relief in 15.56%, and 4) life quality improvement by 36.38%.Conclusions: Clinical improvement and persistent termination of clinical symptoms provide evidence of effectiveness in use of Lactofiltrum combined with the standard treatment of AD.Keywords: atopic dermatitis; Lactofiltrum; lactulose; lignin hydrolysed; allergic disease(Published: 23 June 2016)Citation: Microbial Ecology in Health & Disease 2016, 27: 30418 - http://dx.doi.org/10.3402/mehd.v27.30418
 
Publisher Microbial Ecology in Health and Disease
 
Contributor "AVVA RUS" JSC
 
Date 2016-06-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/30418
10.3402/mehd.v27.30418
 
Source Microbial Ecology in Health and Disease; Vol 27 (2016)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/30418/47353
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30418/47354
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30418/47355
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30418/47356
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30418/24545
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30418/26830
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30418/26831
 
Rights Copyright (c) 2016 Svetlana Zakirova
http://creativecommons.org/licenses/by-nc/4.0
 

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