The composition of the gut microbiota throughout life, with an emphasis on early life

Microbial Ecology in Health and Disease

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Title The composition of the gut microbiota throughout life, with an emphasis on early life
Creator Rodríguez, Juan Miguel
Murphy, Kiera
Stanton, Catherine
Ross, R. Paul
Kober, Olivia I.
Juge, Nathalie
Avershina, Ekaterina
Rudi, Knut
Narbad, Arjan
Jenmalm, Maria C.
Marchesi, Julian R.
Collado, Maria Carmen
Subject gut; microbiota; neonate; diet; maternal
Description The intestinal microbiota has become a relevant aspect of human health. Microbial colonization runs in parallel with immune system maturation and plays a role in intestinal physiology and regulation. Increasing evidence on early microbial contact suggest that human intestinal microbiota is seeded before birth. Maternal microbiota forms the first microbial inoculum, and from birth, the microbial diversity increases and converges toward an adult-like microbiota by the end of the first 3–5 years of life. Perinatal factors such as mode of delivery, diet, genetics, and intestinal mucin glycosylation all contribute to influence microbial colonization. Once established, the composition of the gut microbiota is relatively stable throughout adult life, but can be altered as a result of bacterial infections, antibiotic treatment, lifestyle, surgical, and a long-term change in diet. Shifts in this complex microbial system have been reported to increase the risk of disease. Therefore, an adequate establishment of microbiota and its maintenance throughout life would reduce the risk of disease in early and late life. This review discusses recent studies on the early colonization and factors influencing this process which impact on health.Keywords: gut; microbiota; neonate; diet; maternal(Published: 2 February 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 26050 - paper is part of the Proceedings from the 2013 ENGIHR Conference in Valencia, Spain. More papers from this supplement can be found at
Publisher Microbial Ecology in Health and Disease
Date 2015-02-02
Type info:eu-repo/semantics/article

Format application/pdf
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
Language eng

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