Zinc and copper in animal feed - development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin

Microbial Ecology in Health and Disease

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Title Zinc and copper in animal feed - development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin
Creator Yazdankhah, Siamak
Rudi, Knut
Bernhoft, Aksel
Subject Zinc, copper, animal feed, bacteria, antimicrobial resistance
Description Farmed animals such as pig and poultry receive additional Zn and Cu in their diets due to supplementing elements in compound feed as well as medical remedies. Enteral bacteria in farmed animals are shown to develop resistance to trace elements such as Zn and Cu. Resistance to Zn is often linked with resistance to methicillin in staphylococci, and Zn supplementation to animal feed may increase the proportion of multiresistant E. coli in the gut. Resistance to Cu in bacteria, in particular enterococci, is often associated with resistance to antimicrobial drugs like macrolides and glycopeptides (e.g. vancomycin). Such resistant bacteria may be transferred from the food-producing animals to humans (farmers, veterinarians, and consumers). Data on dose-response relation for Zn/Cu exposure and resistance are lacking; however, it seems more likely that a resistance-driven effect occurs at high trace element exposure than at more basal exposure levels. There is also lack of data which could demonstrate whether Zn/Cu-resistant bacteria may acquire antibiotic resistance genes/become antibiotics resistant, or if antibiotics-resistant bacteria are more capable to become Zn/Cu resistant than antibiotics-susceptible bacteria. Further research is needed to elucidate the link between Zn/Cu and antibiotic resistance in bacteria.Keywords: Zinc; copper; animal feed; bacteria; antimicrobial resistance(Published: 26 September 2014)Citation: Microbial Ecology in Health & Disease 2014, 25: 25862 - http://dx.doi.org/10.3402/mehd.v25.25862
Publisher Microbial Ecology in Health and Disease
Contributor Norwegian Scientific Committee for Food Safety
Date 2014-09-26
Type info:eu-repo/semantics/article

Format application/pdf
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/25862
Source Microbial Ecology in Health and Disease; Vol 25 (2014)
Language eng
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/25862/36017

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