Changes in vaginal microbiota following antimicrobial and probiotic therapy

Microbial Ecology in Health and Disease

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Title Changes in vaginal microbiota following antimicrobial and probiotic therapy
 
Creator Macklaim, Jean M; Western University
Clemente, Jose C; Mount Sinai School of Medicine, New York NY
Knight, Rob; University of Colorado
Gloor, Gregory B; Western University
Reid, Gregor; Lawson Health Research Institute
 
Subject Lactobacillus; bacterial vaginosis; vulvovaginal candidiasis; probiotics
 
Description Background: The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious.Objective and design: We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions.Results: While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged by therapy, Gardnerella vaginalis, Prevotella, Atopobium, Sneathia, and Megasphaera dominated the vagina of women with bacterial vaginosis (BV), and treatment with tinidazole plus Lactobacillus reuteri RC-14+L. rhamnosus GR-1 resulted in an increased relative abundance of indigenous L. iners or L. crispatus.Conclusions: The ability to restore homeostasis provides a rationale for conjoint use of probiotics with antibiotic treatment of BV.Keywords: Lactobacillus; bacterial vaginosis; vulvovaginal candidiasis; probiotics(Published: 14 August 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 27799 - http://dx.doi.org/10.3402/mehd.v26.27799
 
Publisher Microbial Ecology in Health and Disease
 
Contributor : JM received funding from the VoGue CIHR Team grant. This work was supported in part by the Howard Hughes Medical Institute
 
Date 2015-08-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/27799
10.3402/mehd.v26.27799
 
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/27799/41631
http://www.microbecolhealthdis.net/index.php/mehd/article/view/27799/41632
http://www.microbecolhealthdis.net/index.php/mehd/article/view/27799/41635
http://www.microbecolhealthdis.net/index.php/mehd/article/view/27799/41636
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/27799/19553
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/27799/19554
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/27799/22140
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/27799/22141
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/27799/22142
 
Rights Copyright (c) 2015 Microbial Ecology in Health and Disease
http://creativecommons.org/licenses/by-nc/4.0
 

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