Manipulating the gut microbiota to maintain health and treat disease

Microbial Ecology in Health and Disease

View Publication Info
 
 
Field Value
 
Title Manipulating the gut microbiota to maintain health and treat disease
 
Creator Scott, Karen P.
Antoine, Jean-Michel
Midtvedt, Tore
van Hemert, Saskia
 
Subject Clostridium difficile; fecal microbial transplants; inflammatory bowel disease; irritable bowel syndrome; obesity; prebiotics; probiotics
 
Description Background: The intestinal microbiota composition varies between healthy and diseased individuals for numerous diseases. Although any cause or effect relationship between the alterations in the gut microbiota and disease is not always clear, targeting the intestinal microbiota might offer new possibilities for prevention and/or treatment of disease.Objective: Here we review some examples of manipulating the intestinal microbiota by prebiotics, probiotics, and fecal microbial transplants.Results: Prebiotics are best known for their ability to increase the number of bifidobacteria. However, specific prebiotics could potentially also stimulate other species they can also stimulate other species associated with health, like Akkermansia muciniphila, Ruminococcus bromii, the Roseburia/Enterococcus rectale group, and Faecalibacterium prausnitzii. Probiotics have beneficial health effects for different diseases and digestive symptoms. These effects can be due to the direct effect of the probiotic bacterium or its products itself, as well as effects of the probiotic on the resident microbiota. Probiotics can influence the microbiota composition as well as the activity of the resident microbiota. Fecal microbial transplants are a drastic intervention in the gut microbiota, aiming for total replacement of one microbiota by another. With numerous successful studies related to antibiotic-associated diarrhea and Clostridium difficile infection, the potential of fecal microbial transplants to treat other diseases like inflammatory bowel disease, irritable bowel syndrome, and metabolic and cardiovascular disorders is under investigation.Conclusions: Improved knowledge on the specific role of gut microbiota in prevention and treatment of disease will help more targeted manipulation of the intestinal microbiota. Further studies are necessary to see the (long term) effects for health of these interventions.Keywords: Clostridium difficile; fecal microbial transplants; inflammatory bowel disease; irritable bowel syndrome; obesity; prebiotics; probiotics(Published: 2 February 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 25877 - http://dx.doi.org/10.3402/mehd.v26.25877This paper is part of the Proceedings from the 2013 ENGIHR Conference in Valencia, Spain. More papers from this supplement can be found at http://www.microbecolhealthdis.net
 
Publisher Microbial Ecology in Health and Disease
 
Contributor
 
Date 2015-02-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/25877
10.3402/mehd.v26.25877
 
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/25877/38221
http://www.microbecolhealthdis.net/index.php/mehd/article/view/25877/38222
http://www.microbecolhealthdis.net/index.php/mehd/article/view/25877/38223
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library