Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients

Microbial Ecology in Health and Disease

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Field Value
 
Title Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients
 
Creator McDonald, Daniel
Hornig, Mady
Lozupone, Catherine
Debelius, Justine
Gilbert, Jack A.; University of Chicago
Knight, Rob
 
Subject autism; microbiology; microbiome; neurological
 
Description Differences in the gut microbiota have been reported between individuals with autism spectrum disorders (ASD) and neurotypical controls, although direct evidence that changes in the microbiome contribute to causing ASD has been scarce to date. Here we summarize some considerations of experimental design that can help untangle causality in this complex system. In particular, large cross-sectional studies that can factor out important variables such as diet, prospective longitudinal studies that remove some of the influence of interpersonal variation in the microbiome (which is generally high, especially in children), and studies transferring microbial communities into germ-free mice may be especially useful. Controlling for the effects of technical variables, which have complicated efforts to combine existing studies, is critical when biological effect sizes are small. Large citizen-science studies with thousands of participants such as the American Gut Project have been effective at uncovering subtle microbiome effects in self-collected samples and with self-reported diet and behavior data, and may provide a useful complement to other types of traditionally funded and conducted studies in the case of ASD, especially in the hypothesis generation phase.Keywords: autism; microbiology; microbiome; neurological(Published: 9 March 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 26555 - http://dx.doi.org/10.3402/mehd.v26.26555
 
Publisher Microbial Ecology in Health and Disease
 
Contributor DOE, NIH, NSF,
 
Date 2015-03-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/26555
10.3402/mehd.v26.26555
 
Source Microbial Ecology in Health and Disease; Vol 26 (2015)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/26555/38881
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26555/38882
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26555/38883
http://www.microbecolhealthdis.net/index.php/mehd/article/view/26555/38884
 

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