Effect of fragmented Lactobacillus amylovorus CP1563 on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial

Microbial Ecology in Health and Disease

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Title Effect of fragmented Lactobacillus amylovorus CP1563 on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial
 
Creator Nakamura, Futoshi; Calpis Co. Ltd.
Ishida, Yu; Calpis Co. Ltd.
Aihara, Kohtaro; Calpis Co. Ltd.
Sawada, Daisuke; Calpis Co. Ltd.
Ashida, Nobuhisa; Calpis Co. Ltd.
Sugawara, Tomonori; Calpis Co. Ltd.
Aoki, Yumeko; Calpis Co. Ltd.
Takehara, Isao; Clinical Support Corporation
Takano, Kazuhiko; Medical Corporation Hokubukai Utsukushigaoka Hospital
Fujiwara, Shigeru; Calpis Co. Ltd.
 
Subject PPARα/γ dual agonist; fragmented LAB; visceral fat; paraprobiotics; biogenics
 
Description Background: Previously, we showed that fragmented Lactobacillus amylovorus CP1563 (CP1563) functions as a dual agonist of peroxisome proliferator-activated receptor α and γ in vitro and in vivo.Objective: Here, we examined the safety and effect of CP1563 ingestion on body fat in obese class I participants in a double-blinded, placebo-controlled, randomized clinical trial (RCT).Design: In the RCT, 200 participants with a body mass index (BMI) of 25–30 kg/m2 consumed test beverages with or without 200 mg of CP1563 daily for 12 weeks. In total, 197 subjects completed the study without any adverse effects.Results: Body fat percentage, whole body fat, and visceral fat were significantly decreased in the test group compared with the placebo group (p<0.001, p<0.001, and p<0.001, respectively). Triglycerides, total cholesterol, LDL-cholesterol, and diastolic blood pressure showed significant reductions in the test group compared with the placebo group (p<0.001, p<0.001, p<0.001, and p<0.001, respectively). Additionally, significant differences in the changes in blood glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and uric acid were observed between the two groups (p<0.001, p=0.004, p<0.001, and p<0.001, respectively). Improvements in anthropometric measurements and markers were observed in obese class I subjects in the test group.Conclusions: Daily consumption of beverages containing fragmented CP1563 for 12 weeks by obese class I subjects improved anthropometric measurements and markers related to lipid and glucose metabolism without any adverse effects. These results suggest that the consumption of foods containing fragmented CP1563 reduces body fat and prevents metabolic syndrome.Keywords: PPARα/γ dual agonist; fragmented lactic acid bacteria; visceral fat; paraprobiotics; biogenics(Published: 23 May 2016)Citation: Microbial Ecology in Health & Disease 2016, 27: 30312 - http://dx.doi.org/10.3402/mehd.v27.30312
 
Publisher Microbial Ecology in Health and Disease
 
Contributor Asahi Group Holdings Ltd.
Calpis Co., Ltd.
 
Date 2016-05-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.microbecolhealthdis.net/index.php/mehd/article/view/30312
10.3402/mehd.v27.30312
 
Source Microbial Ecology in Health and Disease; Vol 27 (2016)
1651-2235
 
Language eng
 
Relation http://www.microbecolhealthdis.net/index.php/mehd/article/view/30312/46785
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30312/46786
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30312/46787
http://www.microbecolhealthdis.net/index.php/mehd/article/view/30312/46788
http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30312/24312
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http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30312/24321
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http://www.microbecolhealthdis.net/index.php/mehd/article/downloadSuppFile/30312/27803
 
Rights Copyright (c) 2016 Futoshi Nalamura, Yu Ishida, Kotaro Aihara, Daisuke Sawada, Nobuhisa Ashida, Tomonori Sugawara, Yumeko Aoki, Isao Takehara, Kazuhiko Takano, Shigeru Fujiwara
http://creativecommons.org/licenses/by-nc/4.0
 

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