Detection of blaIMP4 and blaNDM1 harboring Klebsiella pneumoniae isolates in a university hospital in Malaysia

Emerging Health Threats Journal

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Title Detection of blaIMP4 and blaNDM1 harboring Klebsiella pneumoniae isolates in a university hospital in Malaysia
 
Creator Hamzan, Nurul Izzati; Universiti Sains Malaysia
Yean Yean, Chan; Universiti Sains Malaysia
Abdul Rahman, Rosliza; Universiti Sains Malaysia
Hasan, Habsah; Universiti Sains Malaysia
Abdul Rahman, Zaidah; Universiti Sains Malaysia
 
Subject Epidemiology
carbapenem-resistant Enterobacteriaceae; carbapenemase; Klebsiella pneumoniae; Modified Hodge test

 
Description Background: Antibiotic resistance among Enterobacteriaceae posts a great challenge to the health care service. The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is attracting significant attention due to its rapid and global dissemination. The infection is associated with significant morbidity and mortality, thus creating challenges for infection control and managing teams to curb the infection. In Southeast Asia, there have been limited reports and subsequent research regarding CRKP infections. Thus, the study was conducted to characterize CRKP that has been isolated in our setting.Methods: A total of 321 K. pneumoniae were included in the study. Each isolate went through an identification process using an automated identification system. Phenotypic characterization was determined using disk diffusion, modified Hodge test, Epsilometer test, and inhibitor combined disk test. Further detection of carbapenemase genes was carried out using polymerase chain reaction and confirmed by gene sequence analysis.Results: All together, 13 isolates (4.05%) were CRKP and the majority of them were resistant to tested antibiotics except colistin and tigercycline. Among seven different carbapenemase genes studied (blaKPC, blaIMP, blaSME, blaNDM, blaIMI, blaVIM, and blaOXA), only two, blaIMP4 (1.87%) and blaNDM1 (2.18%), were detected in our setting.Conclusion: Evidence suggests that the prevalence of CRKP in our setting is low, and knowledge of Carbapenem-resistant Enterobacteriaceae and CRKP has improved and become available among clinicians.Keywords: carbapenem-resistant Enterobacteriaceae; carbapenemase; Klebsiella pneumoniae; Modified Hodge test(Published: 10 March 2015)Citation: Emerg Health Threats J 2015, 8: 26011 - http://dx.doi.org/10.3402/ehtj.v8.26011
 
Publisher Emerging Health Threats Journal
 
Contributor Universiti Sains Malaysia
 
Date 2015-03-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

cross sectional
 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://journals.co-action.net/index.php/ehtj/article/view/26011
10.3402/ehtj.v%v.26011
 
Source Emerging Health Threats Journal; Vol 8 (2015) incl Supplements
1752-8550
1752-8550
 
Language eng
 
Relation http://journals.co-action.net/index.php/ehtj/article/view/26011/38891
http://journals.co-action.net/index.php/ehtj/article/view/26011/38892
http://journals.co-action.net/index.php/ehtj/article/view/26011/38893
http://journals.co-action.net/index.php/ehtj/article/view/26011/38895
http://journals.co-action.net/index.php/ehtj/article/downloadSuppFile/26011/16551
http://journals.co-action.net/index.php/ehtj/article/downloadSuppFile/26011/16552
http://journals.co-action.net/index.php/ehtj/article/downloadSuppFile/26011/19123
 
Coverage south east asia


 

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