Human enterovirus 71 epidemics: what’s next?

Emerging Health Threats Journal

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Title Human enterovirus 71 epidemics: what’s next?
Creator Yip, Cyril C.Y.; University of Hong Kong
Lau, Susanna K.P.; University of Hong Kong
Woo, Patrick C.Y.; University of Hong Kong
Yuen, Kwok-Yung; University of Hong Kong
human enterovirus 71; hand, foot and mouth disease; evolution; genotype; mutation; recombination

Description Human enterovirus 71 (EV71) epidemics have affected various countries in the past 40 years. EV71 commonly causes hand, foot and mouth disease (HFMD) in children, but can result in neurological and cardiorespiratory complications in severe cases. Genotypic changes of EV71 have been observed in different places over time, with the emergence of novel genotypes or subgenotypes giving rise to serious outbreaks. Since the late 1990s, intra- and inter-typic recombination events in EV71 have been increasingly reported in the Asia-Pacific region. In particular, ‘double-recombinant’ EV71 strains belonging to a novel genotype D have been predominant in mainland China and Hong Kong over the last decade, though co-circulating with a minority of other EV71 subgenotypes and coxsackie A viruses. Continuous surveillance and genome studies are important to detect potential novel mutants or recombinants in the near future. Rapid and sensitive molecular detection of EV71 is of paramount importance in anticipating and combating EV71 outbreaks.Keywords: human enterovirus 71; hand, foot and mouth disease; evolution; genotype; mutation; recombination(Published: 10 September 2013)Citation: Emerg Health Threats J 2013, 6: 19780 -
Publisher Emerging Health Threats Journal
Date 2013-09-10
Type info:eu-repo/semantics/article

Format application/pdf
Source Emerging Health Threats Journal; Vol 6 (2013) incl Supplements
Language eng


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