BAALC and ERG Expression in Egyptian Patients with Acute Myeloid Leukemia, Relation to Survival and Response to Treatment

Jurnal Manajemen Pendidikan

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Field Value
 
Title BAALC and ERG Expression in Egyptian Patients with Acute Myeloid Leukemia, Relation to Survival and Response to Treatment
 
Creator Soliman, Aml
Abdel Aal, Asmaa
Afify, Reham
Ibrahim, Noha
 
Subject BAALC
ERG
gene expression
Quantitative real-time RT-PCR
AML
Hematology
 
Description AIM: Aim was to detect Brain and Acute Leukemia, Cytoplasmic (BAALC) and ETS-related gene (ERG) expression in patients with acute myeloid leukemia (AML) as well as to study their biologic and prognostic impact on the disease outcome and survival.PATIENTS AND METHODS: The current study was carried out on 44 patients with denovo acute myeloid leukemia, as well as 44 age and sex matched controls. The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was performed for estimation of BAALC and ERG expression.RESULTS: The current study was carried out on 44 patients with denovo acute myeloid leukemia, as well as 44 age and sex matched controls. The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was performed for estimation of BAALC and ERG expression. BAALC was expressed in 36 (81.82%) of AML cases versus 10 (22.72%) of the control group which was highly statistically significant (P < 0.001). While ERG was positive in 39(88.64%) of cases and 8(18.18 %) of controls and that was also highly statistically significant (P < 0.001).CONCLUSION: Further researches still needed to clarify the role of BAALC and ERG in the pathogenesis of leukemia and their importance as targets for treatment of AML.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2016-05-22
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was performed for estimation of BAALC and ERG expression.
 
Format application/pdf
application/pdf
 
Identifier https://www.id-press.eu/mjms/article/view/oamjms.2016.058
10.3889/oamjms.2016.058
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 4 No. 2 (2016): Jun 15 (OAMJMS); 264-270
1857-9655
 
Language eng
 
Relation https://www.id-press.eu/mjms/article/view/oamjms.2016.058/1022
https://www.id-press.eu/mjms/article/view/oamjms.2016.058/996
 

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