Combined Salvage Therapies for Recurrent Glioblastoma Multiforme Treatment Options in Multifocal and Multicentric Patterns of Recurrence

MedCrave

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Title Combined Salvage Therapies for Recurrent Glioblastoma Multiforme Treatment Options in Multifocal and Multicentric Patterns of Recurrence
 
Creator Archavlis, Eleftherios
 
Description Salvage therapies in recurrent multifocal glioblastoma Background Recurrent glioblastoma multiforme following multimodality therapy have limited palliative treatment options when the major modalities of therapy have been exhausted Moreover multifocal and multicentric bilateral patterns of recurrence is associated with worse prognosis and currently there is no specific treatment protocol for this patient population The authors introduce a clinical and radiological indication solving algorithm and provide outcome rates of a multifocal and multicentric glioblastoma recurrence cohort Methods Consecutive adult patients with multifocal and or multicentric recurrence of glioblastoma who underwent a combined scheme of salvage treatments consisting of high dose rate HDR brachytherapy stereotactic radiosurgery and chemotherapy were included in this retrospective study and were compared to a historical control group of patients who have been treated with intensive temozolomide chemotherapy as the only treatment modality All patients were previously treated with surgery of the primary pathology concomitant and adjuvant radiochemotherapy with temozolomide Results Median survival was months for the entire cohort after salvage treatment and can be translated into a month improvement in survival compared to the control group of patients with glioblastoma recurrence treated with temozolomide alone P HDR Brachytherapy combined with stereotactic radiosurgery and chemotherapy renders acceptable complication rates and seems to be a reasonable salvage option for patients with multifocal and or multicentric recurrent glioblastoma Conclusion Our experience suggests that a combined salvage treatment plan appears to be either feasible or effective and can be considered in selected patients affected by multifocal and multicentric recurrence of glioblastoma The authors rsquo clinical and radiological indication solving algorithm may assist in providing the best possible salvage treatment for this difficult population
 
Publisher Journal of Cancer Prevention & Current Research
 
Date 2017-01-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
text/html
 
Identifier https://medcrave.org/index.php/JCPCR/article/view/3860
 
Source Journal of Cancer Prevention & Current Research; Vol 7, No 7 (2017): Issue 1
2373-633X
2373-633X
 
Language eng
 
Relation https://medcrave.org/index.php/JCPCR/article/view/3860/7690
https://medcrave.org/index.php/JCPCR/article/view/3860/7697
 
Rights Copyright (c) 2020 Eleftherios Eleftherios
https://creativecommons.org/licenses/by-nc/4.0
 

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