Molecular Response of Chronic Myeloid Leukaemia Patients to Tyrosine Kinase Inhibitors

Haematology Journal of Bangladesh

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Title Molecular Response of Chronic Myeloid Leukaemia Patients to Tyrosine Kinase Inhibitors
Creator Hossain, Md. Imran
Yamani, Md. Jaki
Hossain, Md. Golzar
Hossain, Mohammed Murad
Khan, Md. Rafiquzzaman
Aziz, Md. Abdul
Subject Ph chromosome
BCR-ABL1 fusion gene
tyrosine kinase inhibitors
minimal residual disease
Description Background: The goal of therapy in Chronic Myeloid Leukaemia (CML) with tyrosine kinase inhibitors (TKIs) has been to achieve the molecular responses, as measured by the reduction or elimination of BCR-ABLl transcript. Objective: The aim of the study is to observe the molecular response status of CML patients to TKIs. Methodology: This is an observational study and was conducted in the department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from February 2018 to January 2019. A total of 30 diagnosed CML patients on TKIs therapy was checked for quantitative BCR-ABL1 (by qRT-PCR) level. The laboratory monitoring of BCR-ABL1 RNA with RQ-PCR was likely become the model for successful molecular diagnostic monitoring of CML patients to both assess and prognosticate the efficacy of these targeted treatments. Result: Among 30 diagnosed CML patients, the mean age was found 36.1±11.7 years with range from 20 to 70 years. Males were predominant 19 (63.3%), male: female ratio was 1.7:1. Almost two third (63.3%) patients were found optimal (?10%) after 3-month BCR ABL. Age, sex, religion, marital status, occupational status, BMI, monthly income, number of family member, symptoms and sings were not statistically significant (p>0.05) when compared between BCR ABL optimal (?10%) and warning (>10%) group. Mean haemoglobin, total leukocyte count, platelet count, basophil, myelocyte and baseline BCR
ABL1 were not statistically significant (p>0.05) however atypical cells was found statistically significant
Publisher Haematology Society of Bangladesh
Date 2020-05-24
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format application/pdf
Source Haematology Journal of Bangladesh; Vol. 3 No. 02 (2019); 42-46
Language eng
Rights Copyright (c) 2019 Md. Imran Hossain, Md. Jaki Yamani, Md. Golzar Hossain, Mohammed Murad Hossain, Md. Rafiquzzaman Khan, Md. Abdul Aziz

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