Haematological Toxicities Following Treatment of Childhood Hepatoblastoma with Intensive Multiagent Chemotherapy

Haematology Journal of Bangladesh

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Title Haematological Toxicities Following Treatment of Childhood Hepatoblastoma with Intensive Multiagent Chemotherapy
Creator Yasmin, Farida
Jamal, Chowdhury Yakub
Islam, Afiqul
Karim, Md. Anwarul
Begum, Mamtaz
Subject hepatoblastoma
Description Background: Hepatoblastoma is a rare malignant liver tumour that occurs almost exclusively in childhood. Although surgical resection is the foundation of curative therapy, with the use of effective neoadjuvant and adjuvant chemotherapy the 5 years overall survival of patient with hepatoblastoma had recently reached up to 80% to 90 %. But the frequency and severity of haematological toxicity is one of the major concerns of intensive chemotherapy. Objective: To evaluate the frequency and severity of haematological toxicities following treatment of childhood hepatoblastoma with two different regimens of multi-agent chemotherapy. Methodology:  This was a comparative observational study conducted at Bangabandhu Sheikh Mujib Medical university in 24 childhood hepatoblastoma patients who received either cisplatin/carboplatin /doxorubicin (Group A; n=14) or cisplatin/ vincristine/5- fluorouracil (Group B; n= 10) to between March 2010 and July 2014. Results: Grade 3 or 4 anaemia and thrombocytopenia, and Grade 4 neutropenia were observed in 64.3% vs 60%, 35.7% vs 20% and 57.1% vs 20% respectively in group A and Group B. Febrile neutropenia occurred in 100% vs 70% and septicaemia developed in 92.9% vs 70%. Red cell concentrates and Platelet transfusions were required in 35.7% vs 50% and 14.3% vs 10% respectively in two groups. Deaths due to haematological toxicities occurred in 21.4% in Group A and 21% in Group B. Conclusion: We found similar toxicity profiles for two chemotherapy regimens except for higher rates of febrile neutropenia and septicaemia in patients treated with cisplatin/carboplatin /doxorubicin compared to cisplatin/ vincristine/5- fluorouracil.
Publisher Haematology Society of Bangladesh
Date 2020-05-10
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format text/html
Identifier https://journal.hematologybd.org/index.php/haematoljbd/article/view/2
Source Haematology Journal of Bangladesh; Vol. 1 No. 01 (2017); 9-12
Language eng
Relation https://journal.hematologybd.org/index.php/haematoljbd/article/view/2/75
Rights Copyright (c) 2017 Farida Yasmin, Chowdhury Yakub Jamal, Afiqul Islam, Md. Anwarul Karim, Mamtaz Begum

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