Haematological Toxicities Following Treatment of Childhood Hepatoblastoma with Intensive Multiagent Chemotherapy

Haematology Journal of Bangladesh

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Field Value
 
Title Haematological Toxicities Following Treatment of Childhood Hepatoblastoma with Intensive Multiagent Chemotherapy
 
Creator Yasmin, Farida
Jamal, Chowdhury Yakub
Islam, Afiqul
Karim, Md. Anwarul
Begum, Mamtaz
 
Subject hepatoblastoma
chemotherapy
toxicity
children
 
Description Background: Hepatoblastoma is a rare malignant liver tumour that occurs almost exclusively in childhood. Although surgical resection is the foundation of curative therapy, with the use of effective neoadjuvant and adjuvant chemotherapy the 5 years overall survival of patient with hepatoblastoma had recently reached up to 80% to 90 %. But the frequency and severity of haematological toxicity is one of the major concerns of intensive chemotherapy. Objective: To evaluate the frequency and severity of haematological toxicities following treatment of childhood hepatoblastoma with two different regimens of multi-agent chemotherapy. Methodology:  This was a comparative observational study conducted at Bangabandhu Sheikh Mujib Medical university in 24 childhood hepatoblastoma patients who received either cisplatin/carboplatin /doxorubicin (Group A; n=14) or cisplatin/ vincristine/5- fluorouracil (Group B; n= 10) to between March 2010 and July 2014. Results: Grade 3 or 4 anaemia and thrombocytopenia, and Grade 4 neutropenia were observed in 64.3% vs 60%, 35.7% vs 20% and 57.1% vs 20% respectively in group A and Group B. Febrile neutropenia occurred in 100% vs 70% and septicaemia developed in 92.9% vs 70%. Red cell concentrates and Platelet transfusions were required in 35.7% vs 50% and 14.3% vs 10% respectively in two groups. Deaths due to haematological toxicities occurred in 21.4% in Group A and 21% in Group B. Conclusion: We found similar toxicity profiles for two chemotherapy regimens except for higher rates of febrile neutropenia and septicaemia in patients treated with cisplatin/carboplatin /doxorubicin compared to cisplatin/ vincristine/5- fluorouracil.
 
Publisher Haematology Society of Bangladesh
 
Date 2020-05-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
 
Format text/html
application/pdf
 
Identifier https://journal.hematologybd.org/index.php/haematoljbd/article/view/2
10.37545/haematoljbd20172
 
Source Haematology Journal of Bangladesh; Vol. 1 No. 01 (2017); 9-12
2707-1405
2523-1219
 
Language eng
 
Relation https://journal.hematologybd.org/index.php/haematoljbd/article/view/2/75
https://journal.hematologybd.org/index.php/haematoljbd/article/view/2/76
 
Rights Copyright (c) 2017 Farida Yasmin, Chowdhury Yakub Jamal, Afiqul Islam, Md. Anwarul Karim, Mamtaz Begum
https://creativecommons.org/licenses/by-nc/4.0
 

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