Diagnosis of Therapy-related Acute Myeloid Leukemia with t(8;21)(q22;q22.1) after Treatment for Mantle Cell Lymphoma and Oral Squamous Cell Carcinoma

International Journal of Medical and Pharmaceutical Case Reports

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Title Diagnosis of Therapy-related Acute Myeloid Leukemia with t(8;21)(q22;q22.1) after Treatment for Mantle Cell Lymphoma and Oral Squamous Cell Carcinoma
 
Creator Corrêa, Patrícia Colombo
Santos-Pirath, Íris Mattos
Cardoso, Chandra Chiappin
Mattiolo, Camila
Dias, Bruno Vieira
Maioral, Mariana Franzoni
Santos-Silva, Maria Cláudia
 
Description Aims: We report a rare case of therapy-related AML with t(8;21)(q22;q22.1) that occurred after treatment for mantle cell lymphoma (MCL) and oral squamous cell carcinoma (OSCC).
Presentation of Case: A 52 years-old male patient was diagnosed with MCL in leukemic phase. The treatment consisted in R-CHOP rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, then patient experienced remission. Three months later, he presented a lump that was diagnosed as OSCC, which was surgically removed and treated with cisplatin and radiotherapy. Then, the patient’s hemogram presented 35.0% of blasts and, after morphologic, phenotypic and molecular analysis, it was classified as AML with t(8;21)(q22;q22.1). However, due to the previous historic of chemotherapy and radiotherapy, the final diagnosis was t-AML.
Discussion: The correct diagnosis of therapy related malignancies is important due to its severity as they are very aggressive and, usually, considered incurable. t-AMLs with t(8;21)(q22;q22.1) is considered as favorable karyotype, still, it has a poorer outcome compared with its de novo counterpart.
Conclusion: t-AML with t(8;21)(q22;q22.1) is rare and few cases are described in the literature. More reports are necessary to better elucidate the mechanisms involved in this disease to define better treatment strategies to prevent these events and to improve the poor outcomes.
 
Publisher SCIENCEDOMAIN international
 
Date 2019-08-27
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journalijmpcr.com/index.php/IJMPCR/article/view/30104
10.9734/ijmpcr/2019/v12i230104
 
Source International Journal of Medical and Pharmaceutical Case Reports; 2019 - Volume 12 [Issue 2]; 1-7
2394-109X
 
Language eng
 
Relation http://journalijmpcr.com/index.php/IJMPCR/article/view/30104/56482
http://journalijmpcr.com/index.php/IJMPCR/article/view/30104/56483
 
Rights Copyright (c) 2019 © 2019 Corrêa et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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