Adverse Effect of Mixture of Food Additives on Some Biochemical Parameters in Male Albino Rats

JOURNAL OF ADVANCES IN BIOLOGY

View Publication Info
 
 
Field Value
 
Title Adverse Effect of Mixture of Food Additives on Some Biochemical Parameters in Male Albino Rats
 
Creator Radwan, Eman Hashem
Mohamed Elghazaly, Mohamed
Hussein, Hussein Khamis
Abdel Aziz, Karolin Kamel
Barakat, Amel Ibrahim
 
Subject Nephrotoxicity-P53- Oxidative Stress- Food Additives- Male Rats
Histology Physiology
Ecology
 
Description The present study investigated the unsafe impacts of sodium nitrite, sodium benzoate and their mixture which is utilized in fabricating of the food on some biochemical parameters in male albino rats. Rats (40) were divided into four groups as follows: group 1 used as the control, group II and III were treated orally with sodium nitrite nano2 (80 mg/kg BW) and sodium benzoate (SB) (200 mg/kg BW), respectively. Group IV was treated orally with a mixture of sodium nitrite and sodium benzoate. Rats took their respective doses every day for 8 weeks. The obtained results showed that sodium nitrite, sodium benzoate and their mixture (nano2 and SB)  initiated a diminished within in the activity of antioxidant enzymes (SOD, CAT, and GSH) within the kidney, while, MDA recorded a highly significant activity level within experimental groups. Urea and creatinine mean levels were were expanded within plasma of the experimental rats. In the histology of the kidney, sections appeared edema with few mononuclear leukocyte cellular infiltrations, shrinkage of glomeruli. The severity of these changes increased in the experimental group which treated by the mixture of sodium nitrite and sodium benzoate. Overexpression in p53 occurred in experimental groups that were treated by nano2, SB and their mixture. The present study concluded that the mixture of food additives can induce toxicity in the kidney of rats. It is obvious that food additives induced nephrotoxicity  within the kidney. It decreased the antioxidant enzymes (GSH, CAT, and SOD) and increased MDA. Increase tumor suppressor gene p53 in kidney tissue. Food added substances caused changes in biochemical parameters as in creatinine and urea. The utilization of food additives must be decreased. The presence of more than one type of food additives on our food and the usage of the mixture of sodium nitrite and sodium benzoate initiated changes in biochemical parameters and immune-histopathological changes.
 
Publisher KHALSA PUBLICATIONS
 
Date 2020-01-25
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
reviewed Article
 
Format application/pdf
 
Identifier http://rajpub.com/index.php/jab/article/view/8555
10.24297/jab.v13i.8555
 
Source JOURNAL OF ADVANCES IN BIOLOGY; Vol. 13 (2020); 1-13
2347-6893
 
Language eng
 
Relation http://rajpub.com/index.php/jab/article/view/8555/7938
 
Rights Copyright (c) 2020 eman hashem radwan
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library