Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

Acta Brasiliensis

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Title Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

Atividade antimicrobiana de compostos isolados e derivados semissintéticos de Miconia ferruginata
 
Creator Cunha, Gracielle Oliveira Sabbag
Terezan, Ana Paula
Matos, Andreia Pereira
Burger, Marcela Carmen de Melo
Vieira, Paulo Cezar
Fernandes, João Batista
Fernandes da Silva, Maria Fátima das Graças
Menezes, Antônio Carlos Severo
 
Description This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.
Este estudo descreve a avaliação da atividade antimicrobiana de compostos isolados e derivados semissintéticos de Miconia ferruginata (Melastomataceae) contra cinco microorganismos: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442) and Candida albicans (ATCC 10231). A mistura isomérica dos ácidos ursólico e oleanólico foi ativa contra S. aureus (CIM = 250 μg mL-1) e contra E. coli, B. subtilis e P. aeruginosa (CIM = 500 μg mL-1). A flavona 5,6,7-trihidroxi-4’-metóxiflavona e os ésteres metílicos, derivados semissintéticos da mistura dos ácidos ursólico e oleanólico, não apresentaram atividade contra os microrganismos testados. Estes resultados sugerem que o grupo carboxila presente nos triterpenos podem contribuir para a atividade antimicrobiana.
 
Publisher Universidade Federal de Campina Grande - UFCG
 
Date 2020-01-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249
10.22571/2526-4338249
 
Source Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
2526-4338
2526-432X
 
Language eng
 
Relation http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249/87
 
Rights Copyright (c) 2020 Acta Brasiliensis
 

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