Analisis Jumlah Sel Monosit yang Mengekspresikan Tnf-Α setelah dipapar Porphyromonas Gingivalis dan Tulang Ikan Kuniran (Upeneus Sulphureus) dengan Teknik Imunositokimia

Jurnal Kesehatan Gigi

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Title Analisis Jumlah Sel Monosit yang Mengekspresikan Tnf-Α setelah dipapar Porphyromonas Gingivalis dan Tulang Ikan Kuniran (Upeneus Sulphureus) dengan Teknik Imunositokimia
 
Creator Amarta Domini, Fiona Budi
Ratna Dewanti, I Dewa Ayu
Wulandari, Erawati
 
Subject Infamation; TNF-α; Immunomodulatory; nuclear factor kβ (Nf-kβ)
 
Description Monocytes play a role in the first defense against microorganisms that harm the body by activating nuclear factor kβ (Nf-kβ) which is the main regulator of inflammatory genes, one of which is TNF-α. TNF-α at excessive levels will cause tissue damage. Therefore an immunomodulator is needed which can regulate the body's immune system. One natural ingredient that acts as an immunomodulator is fish bones. Purpose of research: To analyze the effect of goatfish’s bone extract on TNF-α expression in human monocytes exposed to P. gingivalis. Method: experimental laboratories in vitro. TNF-α expression was tested by imunocytochemical techniques. Results: The results showed that the average number of monocytes expressing TNF-α in group P1 (group of diclofenac sodium) was 42.33 cells per cell. In the P2 group (P. gingivalis group) was 95 cell percent cells and for P3 (fish bone group) was 74.33 cells per cell and the control group was 11.66 cells per hundred cells. Conclusion: goatfish’s bone extract can act as an anti-inflammatory which is effective in reducing TNF-α expression in monocyte exposed to P. gingivalis but less effective than diclofenac sodium.
 
Publisher Jurusan Keperawatan Gigi, Poltekkes Kemenkes Semarang
 
Contributor
 
Date 2019-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://ejournal.poltekkes-smg.ac.id/ojs/index.php/jkg/article/view/5480
10.31983/jkg.v6i2.5480
 
Source Jurnal Kesehatan Gigi; Vol 6, No 2 (2019): Desember 2019; 87-92
2621-3664
2407-0866
 
Language eng
 
Relation http://ejournal.poltekkes-smg.ac.id/ojs/index.php/jkg/article/view/5480/1483
 
Rights Copyright (c) 2019 Jurnal Kesehatan Gigi
 

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