Evaluation of anti-hyperlipidemic activity in high fat diet induced hyperlipidemic rats of Carissa carandas (Auct.) leaves extract

International Journal of Drug Delivery

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Title Evaluation of anti-hyperlipidemic activity in high fat diet induced hyperlipidemic rats of Carissa carandas (Auct.) leaves extract
 
Creator Tyagi, Chandra Kishore; Sri Satya Sai University of Technology & Medical Sciences, Sehore
Shah, Sunil; Sri Satya Sai University of Technology & Medical Sciences, Sehore
Malviya, Oshine; Sri Satya Sai University of Technology & Medical Sciences, Sehore
 
Subject Pharmaceutical Sciences
Carissa carandas, hyperlipidemia, Cholesterol, atorvastatin
 
Description Hyperlipidemia contributes significantly in the manifestation and development of atherosclerosis and heart disease. Although synthetic lipid‑lowering drugs are useful in treating hyperlipidemia, there are number of adverse effects. Therefore, the current interest has stimulated the search for new lipid‑lowering agents with minimal side effects from natural sources. The Purpose of this study was to examine the lipid lowering capability of aqueous: ethanol (1:1) extract of Carissa carandas in high fat diet induced hyperlipidemic rats. A highly significant increase in the weight of high cholesterol diet rats was observed when compared with control group (P<0.01). The extract caused a significant reduction in body weight, Cholesterol, Triglycerides, HDL and LDL in hyperlipidemic rats. Histopathological changes induced by high cholesterol diet were also significantly reduced by the extract. The activity of ethanol and water extract of C. carandas was comparable to that of atorvastatin. 
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2019-07-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2355
 
Source International Journal of Drug Delivery; Vol 11, No 2 (2019): International Journal of Drug Delivery
0975-0215
 
Language en
 
Relation http://www.arjournals.org/index.php/ijdd/article/downloadSuppFile/2355/907
 
Rights Copyright (c) 2019 Chandra Kishore Tyagi, Sunil Shah, Oshine Malviya
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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