Synthesis and DFT Study of Newly Schiff Base and Fused Heterocyclic Compounds as Antibacterial Agent

JOURNAL OF ADVANCES IN CHEMISTRY

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Field Value
 
Title Synthesis and DFT Study of Newly Schiff Base and Fused Heterocyclic Compounds as Antibacterial Agent
 
Creator Rizk, Sameh
Awheda, Ismail M.
Smida, Fathi A.
 
Subject Oxirane
Pyrazole
Isooxazole
Schiff Base
Imidazole
Triazine
 
Description Treatment of 2,3-di-(4-chlorophenyl) oxirane-2,3-dicarbonitriles(1) with nitrogen nucleophiles, e.g. N2H4, NH2OH afforded pyrazole 2, 1.2oxazole 3 derivatives respectively The 3-amino pyrazole-4-one derivatives 2 can be used as a key starting materials to synthesize some important Schiff base 4 and fused heterocyclic compounds e.g. Imidazolo-[4,5-c]pyrazole 5, Pyrazolo[3,4-e]1,2,4-triazine 6, pyrazol[1,2-a] 1,3,5-triazine 7, 8 and 9. The electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structures of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. The heterocyclic compounds 7, 8 and 9 that contained bridgehead nitrogen gave an excellent result. 
 
Publisher KHALSA PUBLICATIONS
 
Date 2019-11-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://rajpub.com/index.php/jac/article/view/8499
10.24297/jac.v16i0.8499
 
Source JOURNAL OF ADVANCES IN CHEMISTRY; Vol. 16 (2019); 5395-5403
2321-807X
 
Language eng
 
Relation http://rajpub.com/index.php/jac/article/view/8499/7870
 
Rights Copyright (c) 2019 Sameh Rizk, Ismail M. Awheda, Fathi A. Smida
http://creativecommons.org/licenses/by/4.0
 

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