Lapatinib as second-line treatment after the double block pertuzumab-trastuzumab: a case report


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Title Lapatinib as second-line treatment after the double block pertuzumab-trastuzumab: a case report
Creator Magri, Valentina
Scagnoli, Simone
Piesco, Gabriele
Pomati, Giulia
Description We report the case of a young, 36-year-old patient diagnosed with multifocal breast carcinoma, undergoing neoadjuvant chemotherapy, surgery and adjuvant treatment. The patient presented an early recovery of liver disease after only 7 months of free interval. Histological reevaluation after liver biopsy revealed a HER2-positive disease, for which it was treated with first line chemotherapy including double anti-HER2 block. After 3 cycles the disease progressed at liver and encephalic level. It was therefore decided to treat brain localizations with whole-brain radiotherapy and to start a second line with capecitabine associated with lapatinib. This chemo-radiotherapy approach allowed to control the disease for 8 months. Following further progression (lymph node and bone), a third line was chosen with trastuzumab emtansine (TDM1). The encephalic disease remained stable for another 8 months, when due to visceral progression and worsening of clinical picture, TDM1 was interrupted and supportive therapies were started (Oncology).
Publisher Aboutscience Srl
Date 2018-10-31
Type info:eu-repo/semantics/article
Case report
Format application/pdf
Source AboutOpen; V. 4 N. 1 (2018): January - December 2018; 185-190
AboutOpen; Vol 4 No 1 (2018): January - December 2018; 185-190
Language eng
Rights Copyright (c) 2018 The authors

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