Kinetics of Enhancement for Corneal Cross-linking: Proposed Model for a Two-initiator System

Ophthalmology Research: An International Journal

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Title Kinetics of Enhancement for Corneal Cross-linking: Proposed Model for a Two-initiator System
 
Creator Lin, Jui-Teng
 
Description Aims: To derive kinetic equations and analytic formulas for efficacy enhancement of corneal collagen crosslinking (CXL) in a 2-initiator system.
Study Design:  Modeling the kinetics of CXL.
Place and Duration of Study: Taipei, Taiwan, between between January 2019 to June, 2019.
Methodology: Coupled rate equations are derived for two initiators system for a type-II process, consisting of a primary initiator (PA), and a co-initiator (PB) as an enhancer, having 3 cross linking pathways: Two radical-mediated (or electron transfer) pathways, and one oxygen-mediated (or energy transfer) pathway. For a type-II process, the triplet state T* interacts with the co-initiator, PB, to form the primary radicals R’, and an active intermediates radical, R, which could interact with the substrate [M] for crosslink, or be inhibited by oxygen [O2], or bimolecular termination. Rate equations, based on lifetime of triplet-state and oxygen singlet-state, are used to analyze the measured results in a rose-Bengal system with an enhanced initiator.
Results: Additive enhancer-monomer of arginine added to a rose Bengal photosensitizer may enhance the production of free radicals under a green-light CXL. D2O may extends the lifetime of oxygen singlet state and thus improve the efficacy. Our formulas predicted features are consistent with the measured results.
Conclusion: Efficacy may be improved by enhancer-monomer or extended lifetime of photosensitizer triplet-state or oxygen singlet state.
 
Publisher SCIENCEDOMAIN international
 
Date 2019-08-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journalor.com/index.php/OR/article/view/30109
10.9734/or/2019/v10i330109
 
Source Ophthalmology Research: An International Journal; 2019 - Volume 10 [Issue 3]; 1-6
2321-7227
 
Language eng
 
Relation http://journalor.com/index.php/OR/article/view/30109/56492
http://journalor.com/index.php/OR/article/view/30109/56493
 
Rights Copyright (c) 2019 © 2019 Lin; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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