Kinetics of Enhancement for Corneal Cross-linking: Proposed Model for a Two-initiator System

Ophthalmology Research: An International Journal

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Title Kinetics of Enhancement for Corneal Cross-linking: Proposed Model for a Two-initiator System
Creator Lin, Jui-Teng
Description Aims: To derive kinetic equations and analytic formulas for efficacy enhancement of corneal collagen crosslinking (CXL) in a 2-initiator system.
Study Design:  Modeling the kinetics of CXL.
Place and Duration of Study: Taipei, Taiwan, between between January 2019 to June, 2019.
Methodology: Coupled rate equations are derived for two initiators system for a type-II process, consisting of a primary initiator (PA), and a co-initiator (PB) as an enhancer, having 3 cross linking pathways: Two radical-mediated (or electron transfer) pathways, and one oxygen-mediated (or energy transfer) pathway. For a type-II process, the triplet state T* interacts with the co-initiator, PB, to form the primary radicals R’, and an active intermediates radical, R, which could interact with the substrate [M] for crosslink, or be inhibited by oxygen [O2], or bimolecular termination. Rate equations, based on lifetime of triplet-state and oxygen singlet-state, are used to analyze the measured results in a rose-Bengal system with an enhanced initiator.
Results: Additive enhancer-monomer of arginine added to a rose Bengal photosensitizer may enhance the production of free radicals under a green-light CXL. D2O may extends the lifetime of oxygen singlet state and thus improve the efficacy. Our formulas predicted features are consistent with the measured results.
Conclusion: Efficacy may be improved by enhancer-monomer or extended lifetime of photosensitizer triplet-state or oxygen singlet state.
Publisher SCIENCEDOMAIN international
Date 2019-08-10
Type info:eu-repo/semantics/article
Format application/pdf
Source Ophthalmology Research: An International Journal; 2019 - Volume 10 [Issue 3]; 1-6
Language eng
Rights Copyright (c) 2019 © 2019 Lin; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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