Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment

Ophthalmology Research: An International Journal

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Title Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment
Creator Sedhom, Christine R
Abdel-Rahman, Mohamed S
Hussein, Mohamed S
Description Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis.
Study Design:  Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017.
Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results.
Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.
Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.
Publisher SCIENCEDOMAIN international
Date 2019-06-11
Type info:eu-repo/semantics/article
Format application/pdf
Source Ophthalmology Research: An International Journal; 2019 - Volume 10 [Issue 2]; 1-11
Language eng
Rights Copyright (c) 2019 © 2019 Sedhom et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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