Association of carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3) with socio-demographic factors and metastases site in women with metastatic breast cancer in Albania

South Eastern European Journal of Public Health (SEEJPH)

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Title Association of carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3) with socio-demographic factors and metastases site in women with metastatic breast cancer in Albania
 
Creator Hoti, Adrian
Gashi, Edmond
Kraja, Fationa
Sallaku, Agim
 
Subject Albania
bone metastases
breast cancer
cancer antigen 15-3 (CA15-3)
carcinoembryonic antigen (CEA)
hepatic metastases
lung metastases
oncology
tumours
tumour markers.
 
Description Aim: The aim of our study was to assess the association of carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) with socio-demographic factors and metastases site in women diagnosed with metastatic breast cancer in post-communist Albania.Methods: A case-series study was carried out during the period January 2010 – September 2017 including 110 female patients diagnosed with breast cancer with metastases at the Oncology Service of the University Hospital Centre “Mother Teresa” in Tirana, the Albanian capital. Of these, 57 (51.8%) patients had evidence of hepatic metastases, whereas the reaming 53 (48.2%) patients had metastases in the bones and/or in the lungs. CEA and CA15-3 were measured at the time of diagnosis for all study participants. In addition, information on socio-demographic factors was collected. General linear model was used to assess the relationship of CEA and CA15-3 with covariates.     Results: There was evidence of a significant correlation between CEA and CA15-3 levels (Spearman’s rho=0.59, P<0.001). Upon simultaneous adjustment for all covariates, mean values of CEA and CA15-3 were significantly higher in patients with metastases in the bones and/or in the lungs compared with their counterparts with metastases in the liver. Also, CA15-3 levels were significantly higher in younger patients compared with their older counterparts.Conclusion: This study provides valuable evidence on selected correlates of CEA and CA15-3 in Albanian female patients diagnosed with metastatic breast cancer. Oncologists and other health professionals in Albania, as well as decision-makers and policymakers should be aware of the burden and risk factors of breast cancer among women in this transitional society.           
 
Publisher Jacobs Verlag
 
Date 2018-01-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://www.seejph.com/index.php/seejph/article/view/1864
10.4119/seejph-1864
 
Source South Eastern European Journal of Public Health (SEEJPH); Volume IX, 2018
South Eastern European Journal of Public Health (SEEJPH); Volume IX, 2018
2197-5248
 
Language eng
 
Relation https://www.seejph.com/index.php/seejph/article/view/1864/1784
 
Rights Copyright (c) 2018 Adrian Hoti, Edmond Gashi, Fationa Kraja, Agim Sallaku
https://creativecommons.org/licenses/by/4.0
 

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