Antimicrobial peptides, an alternative to combat bacterial resistance

Acta Biológica Colombiana

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Title Antimicrobial peptides, an alternative to combat bacterial resistance
Péptidos antimicrobianos, una alternativa para el combate de la resistencia bacteriana

Creator Mejía-Argueta, Euridice L.
Santillán Benítez, Jonnathan G.
Ortiz-Reynoso, Mariana
Antimicrobial potential; immune system; therapeutic agents

Agentes terapéuticos; potencial antimicrobiano; sistema inmunológico

Description Antimicrobial peptides of higher organisms have been studied for the past 25 years, and their importance as components of innate immunity is now well established. The essential simplicity of their chemical structure, along with the lower likelihood of developed resistance compared to conventional antibiotics, has made them attractive candidates for development as therapeutics. The objective of this review article is to describe the current relevance, main mechanisms presented, and the uses of antimicrobial peptides as new therapies in the clinical area. The information used was mainly compiled from scientific articles based on a systematic review of scientific papers with data on human antimicrobial peptides (AMPs) and their different applications, searching without date limits and only documents in English and Spanish. Gray literature was accessed through manual search, and no restrictions were made involving study design for a retrospective study. Although these products have not yet been commercialized, they have advantages over the currently available treatments since they are not expected to cause bacterial resistance due to their three-dimensional structure, amphipathic tendency, and cationic character; however, the technique of peptide production is still new and is in the early stages of innovation of new molecules.
Los péptidos antimicrobianos de organismos superiores han sido estudiados durante los últimos 25 años y su importancia como componentes de la inmunidad innata está ahora bien establecida. La simplicidad básica de la estructura química de los péptidos antimicrobianos junto con la menor probabilidad de aparición de resistencia en comparación con los antibióticos convencionales los ha convertido en candidatos atractivos para el desarrollo como terapéuticos. El objetivo de este artículo de revisión es describir la relevancia actual, los mecanismos principales que presentan y los usos que se están dando como nuevas terapias en la clínica, donde la información usada es recopilada principalmente de artículos científicos con datos sobre AMPs humanos y sus diferentes aplicaciones. Aunque aún no se comercialicen estos productos, tienen ventajas sobre los tratamientos que ya se tienen, puesto que se prevé no causen resistencia bacteriana, esto debido a su estructura tridimensional, su tendencia anfipática y carácter catiónico. Aunque la técnica de producción de péptidos es aún nueva y están en las primeras etapas de innovación de nuevas moléculas, promete importantes logros en un futuro cercano en el diseño de péptidos más eficientes o que sean estables en diferentes ambientes.

Publisher Universidad Nacional de Colombia - Sede Bogotá - Faculdad de Ciencias - Departamento de Biología
Date 2020-05-01
Type info:eu-repo/semantics/article

Format application/pdf
Source Acta Biológica Colombiana; Vol. 25, Núm. 2 (2020): En prensa / In press
Acta Biológica Colombiana; Vol. 25, Núm. 2 (2020): En prensa / In press
Language eng
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