Pengaruh pemberian ekstrak daun alfalfa (Medicago sativa) terhadap kadar glukosa darah tikus hiperkolesterolemia

Darussalam Nutrition Journal

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Title Pengaruh pemberian ekstrak daun alfalfa (Medicago sativa) terhadap kadar glukosa darah tikus hiperkolesterolemia
Creator Darni, S.Gz., M.Gizi, Joyeti; Universitas Darussalam Gontor
Subject Alfalfa; hyperglycemic; blood glucose
Description Background: Hypercholesterolemic as an indicator of cardiovascular disease is a major cause of morbidity and mortality in the world. Increased oxidative stress in hypercholesterolemic triggers lipid peroxidation effect directly on the cell membrane damage and initiate various diseases. The use of natural materials with relatively few side effects is an  hyperglycemic management alternative. Alfalfa stimulation of insulin secretion, and also improves insulin function by reducing plasma glucose. Experimental studies showed that Alfalfa leaf extract had an effective hypoglycemic activity. Objectives: To determine the effect of Alfalfa leaf extract on blood glucose level of hypercholesterolemic rats. Method: Pre-posttest randomized control group used twenty eight male Sprague Dawley rats were randomly divided into four groups, Sprague Dawley rats without treatment (control), Sprague Dawley rats with extract at dose 20 mg/200 g/d (X1), dose 40 mg/200 g/d (X2), dose 60 mg/200g/d (X3) for 21 days after the rats got hypercholesterolemic. Blood glucose level was measured by GOD-PAP method. Hypothesis test was analyzed by One Way Anova continued by Post hoc LSD test. Results: Alfalfa extract significant decrease in serum total cholesterol (p<0.000). Conclusion: The treatment of Alfalfa (Medicago sativa) leaf extract gives an effect of lower blood glucose level.
Publisher Universitas Darussalam Gontor
Date 2018-12-01
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source Darussalam Nutrition Journal; Vol 2, No 2 (2018): Darussalam Nutrition Journal; 6-13
Language eng
Coverage Pusat Studi Pangan dan Gizi Universitas Gadjah Mada Yogyakarta

Total sampel tikus putih jantan Sprague Dawley berjumlah 28 ekor dengan berat badan 200-250 g dan berumur 8-10 minggu.
Rights Copyright (c) 2018 Darussalam Nutrition Journal

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