Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method

Oceana Biomedicina Journal

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Title Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method
 
Creator Adiwinoto, Ronald Pratama; Airlangga University
Sustini, Florentina; Section of Epidemiology, Department of Public Health and Preventive Medicine, , Airlangga University School of Medicine, Surabaya
Hardiono, Hardiono; Critical Care Medicine, Department of Anesthesiology and Reanimation, Dr. Soetomo General Hospital, Surabaya
Widodo, Agung Dwi Wahyu; Head of Master Program of Immunology Department, Airlangga University School of Medicine, Surabaya
Hidajat, Boerhan; Professor of Clinic, Infection Prevention and Control, Department of Pediatric, Dr. Soetomo General Hospital Surabaya
Hadi, Usman; Professor of Clinic, Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Dr. Soetomo General Hospital Surabaya
 
Description Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of internal medicine department (RPI) of Dr. Soetomo General Hospital from January 2016 to July 2017. Medical records of 91 patients diagnosed with sepsis were collected and studied retrospectively in period from July 2017 to November 2017. 91 (85.05%) medical records from 107 sepsis patients were evaluated. Cultures and antimicrobial sensitivity tests were carried out in 21 (23.07%) patients. 14 patients yielded positive culture results, 9 of which were MDRO positive with ESBL as resistant marker. Empirical antibiotic therapies for these patients were reviewed according to Gyssens method.73 (80.2%) of 91 patients were deemed receiving appropriate empirical antibiotic therapies. Ceftriaxone IV injection as monotherapy or combination therapy were the most common empirical antibiotic therapies (82 in 91 patients, 90.1%), despite local microbiologic flora and antibiogram show most pathogens were resistant to ceftriaxone. Mortality rate in this study was high, 92.3% (84 patients died) despite rational empirical antibiotic therapies were high. This study concluded that empirical antibiotic therapies in sepsis patients according to guidelines adopted in Soetomo General Hospital, albeit deemed rational, was no longer appropriate according to local antibiogram issued by microbiological department of Soetomo General Hospital. Keywords: Empirical Antibiotics Therapy, Gyssens criteria, Intermediate Care Ward, Sepsis, Septic Shock
 
Publisher Universitas Hang Tuah
 
Contributor
 
Date 2018-07-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/17
10.30649/obj.v1i2.17
 
Source Oceana Biomedicina Journal; Vol 1, No 2 (2018): Oceana Biomedicina Journal; 69-78
2614-0519
10.30649/obj.v1i2
 
Language eng
 
Relation http://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/17/10
 
Rights Copyright (c) 2018 Oceana Biomedicina Journal
http://creativecommons.org/licenses/by-nc/4.0
 

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