Discovery of Soil Bacteria Which Display Broad-Spectrum Antibiotic Activity

FAU Undergraduate Research Journal

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Title Discovery of Soil Bacteria Which Display Broad-Spectrum Antibiotic Activity
Creator Martin, Alexis
Copeland, Alexander
Singh, Shweta
Scesa, Paul
West, Lyndon
Baronas-Lowell, Diane
Description Antibiotic-resistant ESKAPE pathogens(Enterococcus faecium, Staphylococcus aureus, Klebsiellapneumoniae, Acinetobacter baumannii, Pseudomonasaeruginosa and Enterobacter species) are the leadingcause of hospital-acquired infections, and thus, thediscovery of novel antibiotics that kill them is crucial. Soilcollected from Palm Beach County by undergraduatesin Life Science Lab (RI:BSC1005L) contained multiplebacterial isolates with broad spectrum antibiotic activity.Soil bacteria that kill the safe relatives of the ESKAPEpathogens and safe models (Erwinia carotovora, Bacillussubtilis and Mycobacterium smegmatis) were characterizedby microbiology assays and bioinformatics to determinetheir identities. Antibiotic compounds were extractedfrom four bacteria that kill both Gram-negative and-positive safe relatives; these bacteria were determinedto be Gram-negative and 83-97% homologous to variousPseudomonas species.
Publisher Florida Atlantic University
Date 2019-06-12
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source FAU Undergraduate Research Journal; Vol 8 No 1 (2019): FAU Undergraduate Research Journal; 25
Language eng
Rights Copyright (c) 2019 FAU Undergraduate Research Journal

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