The Study of Blood Creatinin and Urea Concentration of Wistar Rats (Rattus norvegicus) due to Sodium Nitrite Induction

Jurnal Ilmu Kefarmasian Indonesia

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Title The Study of Blood Creatinin and Urea Concentration of Wistar Rats (Rattus norvegicus) due to Sodium Nitrite Induction
Konsentrasi Kreatinin dan Urea dalam Darah Tikus Putih (Rattus norvegicus) Galur Wistar Akibat Pemberian Natrium Nitrit
 
Creator Widyastuti, Dyah Ayu
Ristianti, Maria Asih
Sari, Ika Maya
 
Description Sodium nitrite is one of common food addition in most meat product. This kind of food preservative is allowed by Permenkes No. 722/Menkes/Per/IX/88 only in minimum doses due to its carcinogenic effect. The most targeted organ is kidney which is sensitive to chemical matter as nefrotoxin. When the kidney is damaged, the erytropoietin secretion to form erytrocite is disturbed. Physiological damage in kidney can be identified by the concentration of blood creatinin and urea. The objective of this research is to study about blood creatinin and urea concentration of Wistar rats which is induced by sodium nitrite. Two groups of Wistar rats were induced by two doses of sodium nitrite (11.25 and 22.50 mg/kg body weight, respectively) a day with one group of control. Blood serum of those three groups were then be analyzed for creatinin and urea concentration each week for three months. The result showed that creatinin concertration is fluctuative during the day one to day ninety. The average of creatinin concentration for two treated groups is not significantly lower than control group. Generally, the urea concentration is increasing for day fourteen to seventy seven then decreasing in day eighty four to ninety. However, there are no significant differences among three groups.
Natrium nitrit adalah bahan pengawet yang sering digunakan untuk olahan daging. Penggunaannya diatur oleh pemerintah melalui Permenkes No. 722/Menkes/Per/IX/88 dengan dosis minimal karena adanya efek karsinogenik. Natrium nitrit seringkali menyerang ginjal sebagai organ target karena organ ini sensitif terhadap senyawa kimia yang bersifat nefrotoksin. Ketika ginjal mengalami kerusakan, sekresi eritropoietin untuk pembentukan eritrosit pun terganggu. Kerusakan fisiologis pada ginjal dapat diidentifikasi melalui kosentrasi kreatinin dan urea pada darah. Tujuan penelitian ini adalah untuk mempelajari konsentrasi kreatinin dan urea pada darah tikus putih galur Wistar yang diberi perlakuan natrium nitrit. Dua kelompok tikus putih galur Wistar diberi perlakuan masing-masing 11.25 dan 22.50 mg/kgBB/hari natrium nitrit, dengan satu kelompok kontrol. Serum darah dari ketiga kelompok tersebut dianalisis konsentrasi kreatinin dan urea nya setiap minggu selama tiga bulan. Hasil penelitian menunjukkan bahwa konsentrasi kreatinin cenderung fluktuatif antara hari pertama hingga ke-sembilan puluh. Rata-rata konsentrasi kreatinin pada dua kelompok perlakuan tidak signifikan lebih rendah dari kelompok kontrol. Secara umum, konsentrasi urea meningkat pada hari ke-empat belas hingga tujuh puluh tujuh, kemudian menurun di hari ke-delapan puluh empat hingga sembilan puluh. Tetapi, konsentrasi kreatinin dan urea pada ketiga kelompok tidak menunjukkan beda nyata.
 
Publisher Fakultas Farmasi Universitas Indonesia
 
Date 2019-04-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/560
10.35814/jifi.v17i1.560
 
Source JURNAL ILMU KEFARMASIAN INDONESIA; Vol 17 No 1 (2019): JIFI; 14-20
2614-6495
1693-1831
 
Language eng
 
Relation http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/560/473
 
Rights Copyright (c) 2019 JURNAL ILMU KEFARMASIAN INDONESIA
 

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