Antidiarrheal Effect of Water Extract of The Nagasari Flowers (Mesua ferrea L.) in BALB/c Mice Induced by Castor Oil

Jurnal Ilmu Kefarmasian Indonesia

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Title Antidiarrheal Effect of Water Extract of The Nagasari Flowers (Mesua ferrea L.) in BALB/c Mice Induced by Castor Oil
Efek Antidiare Ekstrak Air Bunga Nagasari (Mesua Ferrea L.) Terhadap Mencit BALB/c yang Diinduksi Minyak Jarak
 
Creator Puspitarini, Putu Monik Ananta
Pratama, Iman Surya
Suryadi, Bambang Fajar
 
Description Nagasari (Mesua ferrea L.) has a empirically repute for management of diarrhea in West Nusa Tenggara Province. However, the safety and efficacy of the nagasari flowers extract have not been scientifically validated in animal model. This study wasaimed to investigate the antidiarrheal effect of water extract of the nagasari flowers in BALB/c mice. The antidiarrhea activity of nagasari flowerswas investigated using castor oil-induced diarrhea increase in diarrhea index in mice.In castor oil-induced diarrhea test, mice received various consentrations of nagasari flowers extract (0,4% w/v; 0,8% w/v; and 1,6% w/v), where as negative controls received CMC-Na 1% and positive controls received loperamide 0,7 mg/kgBW orally once daily for 1 day and the mice droppings were observed. The phytochemical screening of nagasari flowers contain flavonoid, saponin, and phenolic. Water extract of nagasari flowers at concentration 1,6% showed significant inhibitory activity against castor oil-induced diarrhea when compared with positive controls (diarrhea index 0,083 ; p>0,05). Therefore, this study provides a scientific support for the acclaimed traditional use water extract of Mesua ferrea L. for the treatment of diarrheal diseases.
Nagasari (Mesua ferrea L.) secara empiris digunakan sebagai penanganan diare di Provinsi Nusa Tenggara Barat. Namun, keamanan dan kemanjuran dari ekstrak bunga nagasari belum divalidasi secara ilmiah dalam model hewan. Penelitian ini bertujuan untuk mengetahui efek antidiare ekstrak air bunga nagasari pada mencit BALB/c. Aktivitas antidiare bunga nagasari diteliti dengan menggunakan minyak jarak sebagai penginduksi diare yang meningkatkan indeks diare pada mencit. Pada pengujian diare menggunakan penginduksi minyak jarak, mencit menerima variasi konsentrasi ekstrak bunga nagasari (0,4% b/v; 0,8% b/v; and 1,6% b/v),sedangkan kontrol negatif menerima CMC-Na 1% dan kontrol positif menerima loperamide 0,7 mg/kgBB per oral satu kali sehari selama satu hari dan feses mencit diamati. Skrining fitokimia bunga nagasari mengandung flavonoid, saponin, dan fenolik. Ekstrak air bunga nagasari pada konsentrasi 1,6% menunjukkan aktivitas penghambatan diare yang signifikan terhadap diare yang diinduksi minyak jarak jika dibandingkan dengan kontrol positif (indeks diare 0,083 ; p>0,05). Oleh karena itu, penelitian ini memberikan dukungan ilmiah untuk penggunaan tradisional ekstrak air bunga nagasari untuk penanganan diare.
 
Publisher Fakultas Farmasi Universitas Indonesia
 
Date 2019-04-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/626
10.35814/jifi.v17i1.626
 
Source JURNAL ILMU KEFARMASIAN INDONESIA; Vol 17 No 1 (2019): JIFI; 68-71
2614-6495
1693-1831
 
Language eng
 
Relation http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/626/482
 
Rights Copyright (c) 2019 JURNAL ILMU KEFARMASIAN INDONESIA
 

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