Formula Optimation of Sunflower Oil Cream Formula

Jurnal Ilmu Kefarmasian Indonesia

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Title Formula Optimation of Sunflower Oil Cream Formula
Optimasi Formula Sediaan Krim Sunflower (Helianthus annuus L.) Oil
 
Creator Husein, Eva
lestari, Agatha Budi Susiana
 
Description Sunflower oil is one of the components of moisturizing cream that keeps the moisture of the skin. To produce a good quality cream, it is necessary to select appropriate emulsifying agent. This study aims to find the optimum composition between Tween 80 and Span 80 as an emulsifying agent in the preparation of sunflower oil cream, to meet physical properties and physical stability in terms of viscosity, spread ability and viscosity shift for 30 days. The ability of the cream to maintain skin moisture was tested using the Transepidermal Water Loss (TEWL) method. This study used a 22 experimental research design with the Simplex Lattice Design. The results showed there are 3 formulas of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% that fulfill the requirements with 143,3-153,3 dPas in viscosity, spread ability in range 5,0-5,3 cm, and viscosity shift between 4,3-6,8%. Based on TEWL test, the optimum formula obtained has a moisturizing effect with a TEWL value 17,9-38,0%. It conclude, sunflower oil could be formulated into moisturizing cream using combination of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% to fulfill the requirements for 30 days and could keep the skin moisture.
Minyak biji bunga matahari (sunflower oil) banyak digunakan dalam krim pelembab untuk menjaga kehalusan dan kelembapan kulit. Penggunaan emulgator yang tepat dapat membantu terbentuknya sediaan krim yang stabil. Penelitian ini bertujuan untuk mencari komposisi optimum antara Tween 80 dan Span 80 yang menghasilkan sediaan krim dengan sifat fisik dan stabilitas fisik yang baik ditinjau dari viskositas, daya sebar, dan pergeseran viskositas setelah 30 hari. Kemampuan krim dalam mempertahankan kelembapan kulit diuji dengan metode Transepidermal Water Loss (TEWL). Rancangan penelitian menggunakan Simplex Lattice Design 2 faktor 2 level. Hasil penelitian menunjukkan bahwa dari formula yang diuji, terdapat 3 formula yang memenuhi persyaratan untuk respon yang diuji, yaitu pada kombinasi Tween 80:Span 80 (6:4)%, (7;3)% dan (8:2)%. Viskositas yang diperoleh berada dalam kisaran 143,3-153,3 dPas, daya sebar antara 5,0-5,3 cm, dan pergeseran viskositas antara 4,3-6,8%. Uji TEWL dilakukan terhadap formula optimum yang diperoleh, dan penurunan TEWL yang diperoleh berkisar antara 17,9-38,0%. Berdasarkan data yang diperoleh, dapat disimpulkan bahwa sunflower oil dapat diformulasikan dalam sediaan krim menggunakan kombinasi Tween 80 dan Span 80 pada konsentrasi (6:4)%, (7;3)% dan (8:2)% yang memenuhi persyaratan viskositas, daya sebar, dan pergeseran viskositas selama waktu penyimpanan 30 hari, dan terbukti mampu mempertahankan kelembapan kulit.
 
Publisher Fakultas Farmasi Universitas Indonesia
 
Date 2019-04-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/681
10.35814/jifi.v17i1.681
 
Source JURNAL ILMU KEFARMASIAN INDONESIA; Vol 17 No 1 (2019): JIFI; 62-67
2614-6495
1693-1831
 
Language eng
 
Relation http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/681/481
 
Rights Copyright (c) 2019 JURNAL ILMU KEFARMASIAN INDONESIA
 

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