Anti-obesity Activity Tin Leaf Extract (Ficus carica Linn) on the Rats given High Fat Diets

Jurnal Ilmu Kefarmasian Indonesia

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Title Anti-obesity Activity Tin Leaf Extract (Ficus carica Linn) on the Rats given High Fat Diets
Aktivitas Anti Obesitas Ekstrak Daun Tin (Ficus carica Linn) pada Tikus yang diberi Diet Lemak Tinggi
 
Creator Noordam, Errol Rakhmad
Tamat, Swasono R.
Syamsudin, Syamsudin
 
Description Obesity is a health problem in the community because it can cause a risk of degenerative diseases such as type 2 diabetes mellitus, high blood pressure, heart disease, cancer, and atherosclerosis. Unhealthy lifestyles such as lack of physical activity by exercising, a diet high in carbohydrates and fats, can cause fat deposits in the body, especially in the abdomen. The use of chemical drugs such as Orlistat as a weight loss or to help reduce the risk of regaining lost weight, is less effective because it requires a long consumption time and the presence of side effects. Tin leaf content (Ficus carica Linn) is flavonoids, alkaloids, tannins and steroids, tin leaf extract has IC50 150mg/L antioxidant activity. This study was to determine the anti-obesity activity of tin leaf extract in male Sprague-Dawley rats given a high fat diet. 30 Sprague-Dawley rats were classified into 6 groups. The results obtained, in the group dose of 100 mg / kg obtained an average body weight of 381.8 grams, the test group 200 mg / kg obtained an average body weight of 414.5 grams, in the test group 400 mg / kg obtained 387 grams. The conclusion of this study is that the activity of Tin leaf extract (Ficus carica Linn) can be used as an anti-obesity.
Kegemukan merupakan masalah kesehatan di masyarakat karena dapat menyebabkan resiko penyakit degeneratif seperti diabetes militus tipe 2, tekanan darah tinggi, jantung, kanker, dan aterosklerosis. Gaya hidup yang tidak sehat seperti kurangnya aktivitas fisik dengan berolahraga, diet tinggi karbohidrat dan lemak, dapat menimbulkan timbunan lemak didalam tubuh terutama pada abdomen. Penggunaan obat kimia seperti Orlistat sebagai penurun berat badan atau untuk membantu mengurangi risiko mendapatkan kembali berat badan yang sudah hilang, kurang efektif karena memerlukan waktu konsumsi yang lama dan adanya efek samping. Kandungan daun Tin (Ficus carica Linn) adalah flavonoid, alkaloid, tanin dan steroid, ekstrak daun timah memiliki aktivitas antioksidan IC50 150mg/L. Penelitian ini untuk mengetahui aktivitas anti obesitas ekstrak daun tin pada tikus Sprague-Dawley jantan yang diberikan diet lemak tinggi. 30 tikus Sprague-Dawley diklasifikasikan ke dalam 6 kelompok. Hasil yang diperoleh, pada kelompok dosis 100 mg / kg diperoleh berat badan rata-rata 381,8 gram, kelompok uji 200 mg / kg diperoleh berat badan rata-rata 414,5 gram, pada kelompok uji 400 mg / kg diperoleh 387 gram. Kesimpulan dari penelitian ini adalah aktivitas ekstrak daun Tin (Ficus carica Linn) dapat digunakan sebagai anti-obesitas.
 
Publisher Fakultas Farmasi Universitas Indonesia
 
Date 2019-04-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/700
10.35814/jifi.v17i1.700
 
Source JURNAL ILMU KEFARMASIAN INDONESIA; Vol 17 No 1 (2019): JIFI; 81-86
2614-6495
1693-1831
 
Language eng
 
Relation http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/700/484
 
Rights Copyright (c) 2019 JURNAL ILMU KEFARMASIAN INDONESIA
 

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