Comparison of Lipid Profile in White Rats were given Crude Fucoidan from Brown Seaweed (Sargassum polycystum) that Induced High-Fat Diet

Jurnal Ilmu Kefarmasian Indonesia

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Title Comparison of Lipid Profile in White Rats were given Crude Fucoidan from Brown Seaweed (Sargassum polycystum) that Induced High-Fat Diet
Perbandingan Profil Lipid pada Tikus Putih yang diberi Crude Fucoidan dari Rumput Laut Coklat (Sargassum polycystum) yang Diinduksi Diet Tinggi Lemak
 
Creator Purukan, Juliana Irem Adriana
 
Description : Brown seaweed (Sargassum polycystum) is one of the plants that produces pharmacological activity which is as anti-atherosclerotic with the potential chemical content is fucoidan. The aim of this research is to know the effectiveness of crude fucoidan in decreasing total cholesterol, LDL, TG, increasing HDL levels and atherogenic index. In the optimization phase, 5 rat test animals were used to see the effect of the composition of a high-fat diet given on lipid profiles. While in the testing phase 30 test animals were divided into 6 groups to see the effect of a high-fat and crude fucoidan diet given to lipid profiles. Examination of lipid profiles was carried out three times, namely on the 0th, 14th and 36th days, after that the atherogenic index is calculated. On the 36th day the test, rats were anesthetized and necropsy for subsequent blood collection through the heart organ.The results showed that 200 mg crude fucoidan dose could significantly decreasing total cholesterol, LDL, TG, increased HDL levels and significantly decreased the atherogenic index of rat serum compared to the dosages of 100 mg and 50 mg, but did not differ significantly from the positive control at 10 mg atorvastatin.
Rumput laut coklat (Sargassum polycystum) merupakan salah satu tanaman yang menghasilkan aktivitas farmakologik yaitu sebagai anti aterosklerotik dengan kandungan kimia yang berpotensi adalah fucoidan. Penelitian ini bertujuan untuk mengetahui efektivitas crude fucoidan dalam menurunkan kadar kolesterol, LDL, TG, menaikkan kadar HDL dan Indeks Aterogenik. Pada tahapan optimasi digunakan 5 ekor hewan uji tikus untuk melihat pengaruh komposisi diet tinggi lemak yang diberikan terhadap profil lipid. Sedangkan pada tahap pengujian digunakan 30 ekor hewan uji yang dibagi menjadi 6 kelompok untuk melihat pengaruh diet tinggi lemak dan crude fucoidan yang diberikan terhadap profil lipid. Pemeriksaan profil lipid dilakukan sebanyak tiga kali yaitu pada hari ke-0, ke-14 dan hari ke-36 setelah itu dihitung indeks aterogeniknya. Pada hari ke-36 hewan uji di anestesi dan dinekropsi untuk selanjutnya dilakukan pengambilan darah melalui organ jantung. Hasil penelitian menunjukkan bahwa crude fucoidan dosis 200 mg dapat menurunkan kadar kolesterol total, LDL, TG, menaikkan kadar HDL dan memiliki penurunan indeks aterogenik serum tikus secara bermakna dibandingkan dengan dosis 100 mg dan 50 mg, tetapi tidak berbeda bermakna dengan kontrol positif atorvastatin dosis 10 mg.
 
Publisher Fakultas Farmasi Universitas Indonesia
 
Date 2019-04-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/648
10.35814/jifi.v17i1.648
 
Source JURNAL ILMU KEFARMASIAN INDONESIA; Vol 17 No 1 (2019): JIFI; 46-55
2614-6495
1693-1831
 
Language eng
 
Relation http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/648/479
 
Rights Copyright (c) 2019 JURNAL ILMU KEFARMASIAN INDONESIA
 

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