Hubungan ekspresi RANKL dengan derajat destruksi tulang akibat kolesteatoma pada otitis media supuratif kronik

Oto Rhino Laryngologica Indonesiana

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Title Hubungan ekspresi RANKL dengan derajat destruksi tulang akibat kolesteatoma pada otitis media supuratif kronik
 
Creator Yarisman, Lilia
Asroel, Harry Agustaf
Aboet, Askaroellah
Zaluchu, Fotarisman
 
Description Latar belakang: Otitis media supuratif kronik (OMSK) dengan kolesteatoma merupakan penyakitpada telinga tengah dengan salah satu komplikasi berupa destruksi tulang, yang dapat menyebabkankematian. Receptor Activator of Nuclear Factor Kβ-Ligand (RANKL) merupakan salah satu sitokinyang berperan dalam proses destruksi tulang.Tujuan: Mengetahui hubungan ekspresi RANKL denganderajat destruksi tulang akibat kolesteatoma pada penderita OMSK tipe bahaya.Metode: Penelitian inibersifat analitik dengan desain cross sectional. Sebanyak 40 sampel kolesteatoma dilakukan pemeriksaanimunohistokimia untuk dinilai ekspresi RANKL pada kolesteatoma.Hasil: Terdapat hubungan yangsignifikan antara ekspresi RANKL dengan derajat destruksi tulang dan komplikasi yang terjadi (p<0,05).Tidak terdapat hubungan antara ekspresi RANKL dengan kelompok umur dan jenis kelamin (p>0,05).Kesimpulan: Terdapat hubungan yang signifikan antara derajat destruksi tulang dengan ekspresi RANKLmelalui pemeriksaan imunohistokimia.Kata kunci: RANKL, destruksi tulang, kolesteatoma, OMSK ABSTRACTBackground: Chronic suppurative otitis media (CSOM) with cholesteatoma is a middle ear disease,leading to bone structure destruction which can cause fatal case. Receptor Activator of Nuclear FactorKβ-Ligand (RANKL) is known as one of the cytokine that has important role in the process of bonedestruction.Purpose: To identify an association between RANKL expression with bone destruction leveldue to cholesteatoma in malignant CSOM patients. Method: This was an analytical study with crosssectional design. About 40 cholesteatoma sample was examinated by using immunohistochemistry tomeasure its RANKL expression. Result: There was a significant relationship (p<0.05) between RANKLexpression with bone destruction level and complication. There was no significant relationship betweenRANKL expression with age and sex (p>0.05). Conclusion: There was a significant relationship betweenbone destruction level with the RANKL expression by immunohistochemistry examination.Keywords: RANKL, bone destruction, cholesteatoma, CSOM
 
Publisher PERHATI-KL
 
Contributor
 
Date 2017-07-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://orli.or.id/index.php/orli/article/view/189
10.32637/orli.v47i1.189
 
Source Oto Rhino Laryngologica Indonesiana; Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017; 1-10
2598-3970
0216-3667
10.32637/orli.v47i1
 
Language eng
 
Relation http://orli.or.id/index.php/orli/article/view/189/149
 

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