Pengaruh imunoterapi spesifik terhadap adenoid pada pasien rinitis alergi

Oto Rhino Laryngologica Indonesiana

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Title Pengaruh imunoterapi spesifik terhadap adenoid pada pasien rinitis alergi
 
Creator Pratita, Nindya
Madiadipoera, Teti
Ratunanda, Sinta Sari
Dermawan, Arif
Boesoirie, Shinta Fitri
 
Description Latar belakang: Rinitis alergi (RA) adalah suatu reaksi inflamasi hidung yang diperantarai oleh IgE, dengan gejala hidung tersumbat, rinore, bersin, dan rasa gatal, akibat mukosa hidung terpapar alergen.Hipertrofi adenoid (HA) dianggap sebagai salah satu komorbid dari RA, sehingga mungkin terdapathubungan antara RA dengan HA.Tujuan: Mengetahui pengaruh imunoterapi spesifik terhadap penurunanukuran adenoid pada pasien RA.Metode: Penelitian dilakukan dengan desain quasi-eksperimental,menggunakan anamnesis, nasoendoskopi, dan skin prick test (SPT). Pengukuran derajat adenoid dilakukanpada 32 sampel di Poliklinik Rinologi-Alergi Ilmu Kesehatan Telinga Hidung Tenggorok Bedah Kepala- Leher Rumah Sakit Dr. Hasan Sadikin Bandung selama Februari – Juni 2015. Penelitian ini dibagimenjadi dua kelompok yaitu kelompok pasien RA dengan HA sebagai komorbid yang mendapatkanpengobatan imunoterapi spesifik, dan kelompok yang mendapatkan terapi medikamentosa kombinasiberupa fluticasone furoate dengan cetirizine.Hasil: Pada kelompok yang diberikan imunoterapi spesifik,terjadi penurunan ukuran adenoid yang bermakna, dibandingkan dengan kelompok yang diberikan terapimedikamentosa kombinasi. Persentase penurunan untuk kelompok imunoterapi spesifik sebesar 80,4%,sedangkan pada kelompok pembanding sebesar 60,5%.Kesimpulan: Terdapat penurunan ukuran adenoidsecara signifikan pada kelompok yang mendapatkan pengobatan imunoterapi spesifik, yang lebih baikjika dibandingkan terapi medikamentosa kombinasi.Kata kunci: Rinitis alergi, hipertrofi adenoid, imunoterapi spesifik ABSTRACTBackground: Allergic rhinitis (AR) is an IgE-mediated inflammation reaction of the nosecharacterized by specific symptoms of nasal obstruction, rhinorrhea, sneezing, and nasal itching, whenthe nasal mucous membrane was exposed to allergen. Adenoid hyperthrophy (AH) is considered to beone of AR comorbid factor, and there might be a relationship between AR and AH. Purpose: To evaluatethe effect of specific immunotherapy in decreasing the size of AH in AR’s patients. Methods: This studydesign was a quasi-experimental. We used anamnesis, nasoendoscopic finding, and skin prick test.Measurement of adenoid had been conducted on 32 subjects in the Rhinology-Allergy Clinic of ORL-HNSDepartement of Dr. Hasan Sadikin General Hospital during February – June 2015. This study was dividedinto a group which was given specific immunotherapy, and a group which was given medical treatmentin the form of combination fluticasone furoate and cetirizine. Results: The group which was treated withspecific immunotherapy showed a significant decrease of the adenoid size compared to the group withcombination medication of fluticasone furoate and cetirizine. Specific immunotherapy decreased adenoidsize up to 80.4%, while in the other group was 60.5%.Conclusion: The study showed that the decreaseof adenoid size in the group treated with specific immunotherapy treatment was better than the grouptreated with combined medication treatment.Keywords: Allergic rhinitis, adenoid hyperthrophy, specific immunotherapy
 
Publisher PERHATI-KL
 
Contributor
 
Date 2017-07-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://orli.or.id/index.php/orli/article/view/194
10.32637/orli.v47i1.194
 
Source Oto Rhino Laryngologica Indonesiana; Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017; 42-50
2598-3970
0216-3667
10.32637/orli.v47i1
 
Language eng
 
Relation http://orli.or.id/index.php/orli/article/view/194/154
 

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