Spontaneous Clearance of Chronic HCV: The Key Ending Left in the Dark

Journal of Business & Economics Research (JBER)

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Title Spontaneous Clearance of Chronic HCV: The Key Ending Left in the Dark
Creator Mumdzhiev, Nikola Hristov
Radicheva, Daniela Valerieva
Radicheva, Mariana Penkova
Tenev, Rumen Valchev
Vasileva, Zlatina Dimitrova
Subject Hepatitis C
spontaneous clearance
interferon free treatment
Description BACKGROUND: Hepatitis C is the second leading cause of liver cirrhosis and hepatocellular carcinoma. Although the discovery of direct-acting agents made the disease curable, HCV elimination can be achieved solely by the host’s immunologic arsenal.
CASE REPORT: We report the case of a 29-year-old woman with chronic hepatitis C infection - elevated transaminases, positive serology. HCV was detectable on two occasions, and histology showed mild disease - A1F1. Upon follow up and without any treatment, the patient achieved spontaneous clearance confirmed by two consecutive undetectable HCV RNA tests. Spontaneous HCV clearance rarely occurs – 0.5% per person-year. This is sometimes accompanied by special circumstances like additional disease or medical interventions. Host factors like gender and interleukin-28B polymorphisms have been known to contribute to clearance. Viral factors like HCV RNA levels are also a factor. The characteristics of host-viral interplay – age of acquisition and fibrosis stage – cannot be overlooked.
CONCLUSION: All of the abovementioned factors contribute to the complex immunological interaction between virus and host and the result, although rarely can be spontaneous clearance.
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia; ID Design 2012/DOOEL Skopje, Republic of Macedonia
Date 2019-05-27
Type info:eu-repo/semantics/article
Format application/pdf
Identifier https://www.id-press.eu/mjms/article/view/oamjms.2019.134
Source Open Access Macedonian Journal of Medical Sciences; Vol 7 No 10 (2019): May 31 (OAMJMS); 1657-1659
Language eng
Relation https://www.id-press.eu/mjms/article/view/oamjms.2019.134/3412
Rights Copyright (c) 2019 Nikola Hristov Mumdzhiev, Daniela Valerieva Radicheva, Mariana Penkova Radicheva, Rumen Valchev Tenev, Zlatina Dimitrova Vasileva

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