The effect of albendazole toward anemia in children with soil-transmitted helminths infection in a remote and endemic area

Medical Journal of Indonesia

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Title The effect of albendazole toward anemia in children with soil-transmitted helminths infection in a remote and endemic area
 
Creator Sungkar, Saleha; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta
Tambunan, Fitry B.J.; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta
Gozali, Meutia N.; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta
Kusumowidagdo, Gladys; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta
Wahdini, Sri; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta
 
Subject albendazole; anemia; soil-transmitted helminths; triple dose
 
Description Background: Soil-transmitted helminths (STH) infections lead to nutritional disorder and anemia among children. Albendazole 400 mg is used to control STH, although it has a low cure rate for Trichuris trichiura. The effectiveness of albendazole could be increased by giving a dose of 400 mg for 3 consecutive days. The aim of the study was to investigate the effectiveness of the triple-dose albendazole 400 mg course in decreasing STH and anemia prevalence.Methods: This study used an experimental comparative design conducted in July 2016 and January 2017 in Perobatang Village, Southwest Sumba, Indonesia. Children aged 1–15 years were asked to collect fecal samples to be examined using a Kato-Katz method. Hemoglobin level (Hb) was tested using a rapid test diagnostic strip. STH positive subjects were given 400 mg of albendazole for 3 days witnessed by the researchers. Six months after, the stool samples and Hb levels were re-examined (post-test).Results: From the 156 subjects examined (pretest), the prevalence of Ascaris lumbricoides, Trichuris trichiura, and hookworm were 65.4%, 55.8%, and 15.4%, respectively, and the prevalence of anemia was 71.2%. On post-test, the prevalence of A. lumbricoides, T. trichiura, and hookworm decreased to 8.3%, 12.8%, and 0%, respectively, and the prevalence of anemia decreased to 25%. There was a significant difference in the prevalence of STH infection and anemia before and after the administration of triple-dose albendazole (p=0.001).Conclusion: The triple-dose albendazole is effective in reducing the prevalence of STH and anemia in children with STH infection.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor Directorate of Research and Public Services Universitas Indonesia (Direktorat Riset dan Pengabdian kepada Masyarakat Universitas Indonesia)
 
Date 2018-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/2857
10.13181/mji.v27i4.2857
 
Source Medical Journal of Indonesia; Vol 27, No 4 (2018): December; 293-8
2252-8083
0853-1773
10.13181/mji.v27i4
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/2857/1261
 
Rights Copyright (c) 2018 Saleha Sungkar, Fitry B.J. Tambunan, Meutia N. Gozali, Gladys Kusumowidagdo, Sri Wahdini
http://creativecommons.org/licenses/by-nc/4.0
 

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