ASSESSMENT OF SERUM PARAOXONASE-1 ENZYME ACTIVITY, MALONDIALDEHYDE AND VITAMIN-C IN ORAL PREMALIGNANCIES

International Journal of Clinical and Biomedical Research

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Title ASSESSMENT OF SERUM PARAOXONASE-1 ENZYME ACTIVITY, MALONDIALDEHYDE AND VITAMIN-C IN ORAL PREMALIGNANCIES
 
Creator Param, Kar
Kanchan, Mohod
Manish, Puttewar
Satish, Kumar
 
Description Background:  Oral  premalignancies  are  a  group  of  disease  or  syndromes  which  if  left untreated can lead to cancer. It carries a great significance in Indian perspective. The actual figure  of  oral  cancers  arising  from  oral  premalignancies  is  not  known  and  to  predict accurately the malignant transformations of them is still not possible. Oxidative stress is a known player behind cancerogenesis.  Recently decreased Paraoxonase-1 activity and increased oxidative stress markers ware found to be associated with Oral Squamous Cell Carcinoma. So, there is a strong possibility of a similar finding in Oral Premalignancies too. Aim:  This study aims to investigate the correlation between serum PON-1 activity and oxidative stress markers (MDA & Vitamin C) in patients with Oral Premalignancies. Material and Methods: A total of 62 patients with clinically diagnosed oral premalignant lesions and diseased controls were chosen for the study.  Venous blood samples were collected and PON-1, MDA (in serum) & Vitamin c (in plasma) were analysed spectro-photometrically. Results:   A   significant   decreased   serum   PON-1   activity   (P<0.05)   and   concomitant significantly increased serum MDA (P <0.05) and decreased Vitamin C levels (P<0.05) were observed in premalignancies compared to the controls. These finding were more pronounced in Oral Leukoplakia (OL) than in Oral Submucous Fibrosis (OSMF) with a significant difference. Mean levels of the analysed parameters differed accordingly in the clinical grades of oral premalignancies. Conclusion: It can be envisaged that serum PON-1 activity and increased oxidative stress might be a contributing factor behind pathogenesis and progression of Oral Premalignant Diseases.
 
Publisher Sumathi Publications
 
Contributor
 
Date 2018-07-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://sumathipublications.com/index.php/ijcbr/article/view/215
10.31878/ijcbr.2018.43.05
 
Source International Journal of Clinical and Biomedical Research; Volume 4, Issue 3; July 2018; 21-26
2395-0471
2521-0394
 
Language eng
 
Relation http://sumathipublications.com/index.php/ijcbr/article/view/215/252
 
Rights Copyright (c) 2018 Kar Param, Mohod Kanchan, Puttewar Manish, Kumar Satish
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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