PROTECTIVE EFFECT OF DIOSGENIN AGAINST CARBON TETRACHLORIDE AND CISPLATIN INDUCED HEPATOTOXICITY IN RATS

International Journal of Clinical and Biomedical Research

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Field Value
 
Title PROTECTIVE EFFECT OF DIOSGENIN AGAINST CARBON TETRACHLORIDE AND CISPLATIN INDUCED HEPATOTOXICITY IN RATS
 
Creator Nimbalkar, Vikram V
Shelke, Ravina P
Kadu, Urmila E
Gaikwad, Pandurang M
 
Description Background: Activation of hepatic stellate cells (HSC) plays central role in the development of liver fibrosis. In HSC activation, the transforming growth factor-β1 (TGF-β1) is considered to be the main stimuli factor. Diosgenin are the steroidal saponin and found in Trigonella foenum graecum Linn (Fenugreek) and some other species of Dioscorea. Diosgenin attenuates HSC activation by inhibiting transforming growth factor-β. Aim: In present study an attempt was made to explore the effect of diosgenin on liver fibrosis. Methods: Liver fibrosis was induced in rats by carbon tetrachloride (CCl4) 1 ml/kg intraperitoneally twice a week for 28 days and cisplatin 3mg/kg intraperitoneally at 0, 1, 3 week for 4 weeks. The extent of liver fibrosis was assessed by measuring the weight of liver and levels of total bilirubin (TBL), hydroxyproline (HP) and serum enzymes due to deposition of extracellular matrix (ECM). Results: The administration of diosgenin reduced the liver weight of CCl4 and cisplatin treated animals and reduced the TBL, HP level and serum enzymes significantly and inhibited liver fibrosis induced by CCl4 and cisplatin. Conclusion: The result obtained in the present investigation, Diosgenin treatment exerted significant hepatoprotective effect in animals by inhibiting ECM deposition and HSCs activation. 
 
Publisher Sumathi Publications
 
Contributor
 
Date 2018-07-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://sumathipublications.com/index.php/ijcbr/article/view/225
10.31878/ijcbr.2018.43.11
 
Source International Journal of Clinical and Biomedical Research; Volume 4, Issue 3; July 2018; 50-56
2395-0471
2521-0394
 
Language eng
 
Relation http://sumathipublications.com/index.php/ijcbr/article/view/225/259
 
Rights Copyright (c) 2018 Vikram V Nimbalkar, Ravina P Shelke, Urmila E Kadu, Pandurang M Gaikwad
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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