COMPARATIVE STUDY OF COMMONLY PRACTICED ATROPINIZATION REGIMENS IN ACUTE ORGANOPHOSPHORUS COMPOUND POISONING

International Journal of Clinical and Biomedical Research

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Field Value
 
Title COMPARATIVE STUDY OF COMMONLY PRACTICED ATROPINIZATION REGIMENS IN ACUTE ORGANOPHOSPHORUS COMPOUND POISONING
 
Creator Singh, Supriya
RC, Bidri
Badiger, Veeresh
 
Description Aim of the study: Effect of atropinization with different methods. Outcomes in terms of duration of hospital stay and patients recovery. Methodology: An open-label randomized clinical trial was conducted in, Shri B M Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka. 108 individuals with OPC poisoning .We compared two groups that used a titrated dosing protocol based on a structured monitoring sheet for atropine infusion with another group using an ‘ad hoc’ regime. The aim was to compare the efficacy and safety of conventional bolus doses with individualized incremental doses of atropine for atropinization followed by continuous atropine infusion for management of OPC poisoning. Result: Out of 108 patients, 54 patients received conventional bolus dose atropine (group A) and 54 patient received rapidly incremental doses of atropine followed by infusion (group B).36 subjects analyzed in group A and 32 in group B for moderate to severe poisoning. The mortality in group A was 11.1%(4/36) and in group B was 6.3%(2/32).The mean duration of atropinization in group A was 5.8hrs (348) in minutes compared to time 26.9minutes for group B. Conclusion: Administration of atropine using a fixed algorithm is easy and effective in providing the atropine requirement in management of early phase of acute OPC poisoning. Rapid incremental dose atropinization followed by atropine infusion reduces mortality and morbidity from OPC poisoning and shortens the length of hospital stay and early recovery .Incremental atropine and infusion should become the treatent of choice for OPC poisoning.Keywords: Organophosphate compound; Atropine toxicity; Organophosphorus poisoning; Atropinization protocols.
 
Publisher Sumathi Publications
 
Contributor
 
Date 2018-04-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://sumathipublications.com/index.php/ijcbr/article/view/202
10.5455/ijcbr.2018.42.13
 
Source International Journal of Clinical and Biomedical Research; Volume 4, Issue 2; April 2018; 56-64
2395-0471
2521-0394
 
Language eng
 
Relation http://sumathipublications.com/index.php/ijcbr/article/view/202/236
 
Rights Copyright (c) 2018 Supriya Singh, Bidri RC, Veeresh Badiger
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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