EFFECT OF STRESS ON HISTOPATHOLOGY OF MALE REPRODUCTIVE SYSTEM IN RATS

International Journal of Current Research in Physiology and Pharmacology (IJCRPP)

View Publication Info
 
 
Field Value
 
Title EFFECT OF STRESS ON HISTOPATHOLOGY OF MALE REPRODUCTIVE SYSTEM IN RATS
 
Creator Sangishetti, Vijay Prasad
DH, Nandal
BB, Nayak
BB, Ghongane
BB, Shinde
R, Kunkulol R
 
Description Background: Although relatively little is known about factors affecting fertility. Latest literature suggests that environmental and lifestyle factors play an important role. Recently, oxidative stress has become the focus of interest as potential cause of male infertility. Oxidative stress may play a role in a number of conditions known to be detrimental to male fertility Method: Adult male albino rats weighing 200 – 220 g and aged 12-15 weeks male rats were selected for the study. The rats were randomly analyzed into 3 groups Group 1: Control rat, Group 2: Swimming stress without treatment, Group 3: Treated with vitamin C 30mg/kg/day doses. All rats were subjected to swimming stress daily between 09.00AM to 10.00AM until 50 days. Drugs were administered orally for 50 days half an hour before subjecting to stress. At end of the study the reproductive organs testes, seminal vesicles, Vas deferens and prostate were dissected and the samples were used for the histo-pathological evaluation.   Result: In stress group section of testis shows seminiferous tubules showed focial poor spermatogenesis with reduction in number of sperm containing seminiferous tubules and absence of spermatozoa was clearly recognized in some seminiferous tubules. Treatment with antioxidant showed recovery but still some of the seminiferous tubules showed decreased spermatozoa. Stress changes in seminal vesicle:  the hyperplasia of epithelial lining, histological features of mucosa severely affected and reduced number of gland. Stress induced changes in vas deferens:  produced desquamated ling epithelium with atrophic changes and mild exploited epithelium, degenerated basement membrane of vas deferens. Stress induced changes in prostate: Prostatic acini with many papillary folds, desquamated epithelial cells, epithelial proliferation was seen. Conclusion: Oxidative stress produced deleterious effects on male reproductive system and supplementation of antioxidants such as vitamin C have been shown to be protecting effect against the histological changes produced by the oxidative stress on male reproductive system in rats.KEYWORDS:  Stress; Male reproductive organs; Histopathology; Rats
 
Publisher Sumathi Publications
 
Contributor
 
Date 2017-12-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.sumathipublications.com/index.php/ijcrpp/article/view/4
 
Source International Journal of Current Research in Physiology and Pharmacology (IJCRPP); Vol 1, No 1 (2017); 13-18
2523-6709
2523-6695
 
Language eng
 
Relation http://www.sumathipublications.com/index.php/ijcrpp/article/view/4/17
 
Rights Copyright (c) 2018 Vijay Prasad Sangishetti, Nandal DH, Nayak BB, Ghongane BB, Shinde BB, Kunkulol R R
https://creativecommons.org/licenses/by-nc-sa/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library