Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

Fisioterapia em Movimento

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Title Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly
Creator Gazolla de Macedo, Barbara
de Oliveira, Hanna Sette Câmara
Viotti de Paula, Marielle
Gomes, Gisele de Cássia
Antunes, Carlos Maurício de Figueiredo
Description Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: Assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Materials and Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging. 
Publisher Editora PUCPRESS
Date 2018-10-04
Type info:eu-repo/semantics/article

Format application/pdf
Source Fisioterapia em Movimento (Physical Therapy in Movement); v. 31 (2018): n. cont.; 1 - 11
Fisioterapia em Movimento; v. 31 (2018): n. cont.; 1 - 11
Language por
Rights Direitos autorais 2018 Fisioterapia em Movimento

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