Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

Fisioterapia em Movimento

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Field Value
 
Title Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly
 
Creator Gazolla de Macedo, Barbara
de Oliveira, Hanna Sette Câmara
Viotti de Paula, Marielle
Gomes, Gisele de Cássia
Antunes, Carlos Maurício de Figueiredo
 
Description Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: Assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Materials and Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging. 
 
Publisher Editora PUCPRESS
 
Contributor
 
Date 2018-10-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


 
Format application/pdf
 
Identifier https://periodicos.pucpr.br/index.php/fisio/article/view/24009
10.1590/1980-5918.031.ao32
 
Source Fisioterapia em Movimento (Physical Therapy in Movement); v. 31 (2018): n. cont.; 1 - 11
Fisioterapia em Movimento; v. 31 (2018): n. cont.; 1 - 11
1980-5918
0103-5150
 
Language por
 
Relation https://periodicos.pucpr.br/index.php/fisio/article/view/24009/pdf
 
Rights Direitos autorais 2018 Fisioterapia em Movimento
 

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