The Effect of Crospovidone on the Dissolution Profile of Amlodipine Besylate from Fast Orally Dissolving Film


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Title The Effect of Crospovidone on the Dissolution Profile of Amlodipine Besylate from Fast Orally Dissolving Film
Creator Sumaiyah, Sumaiyah
Mentari, Julia
Suryanto, Suryanto
Subject amlodipine besylate
solvent casting
fast orally dissolving film
Description BACKGROUND: Fast Orally Dissolving Film preparation can be used for patients with problems in ingesting solid dosage forms, such as mentally ill, elderly, geriatric and patients who are reducing fluid intake or nausea.
AIM: This study aimed to formulate and evaluate the rapid dissolution of amlodipine besylate.
METHODS: Amlodipine besylate film was prepared by solvent casting method by using hydroxypropyl methylcellulose (HPMC) as film formers, crospovidone as superdisintegrant with Varian concentration F1 (2%), F2 (4%), F3 (6%) and F4 (8%), PEG 400 as plasticizer, sucralose and sorbitol as sweetener, citric acid as saliva stimulation, and grape essence as flavoring and coloring agent. Characteristics of films include organoleptic, weight uniformity, film thickness, surface pH, swelling, uniformity of content, time of disintegration, and dissolution.
RESULTS: All formulated films produced a good film, smooth, transparent and uniform physical properties. F2 with polymer HPMC and the 4% concentration of crospovidone was the best formula with 31.50 seconds of disintegration time, the index expanding at the 15 second by 242.29% and the cumulative percent of the drug at 80 seconds by 98.08%.
CONCLUSION: Amlodipine besylate can be formulated into fast orally dissolving film preparations using HPMC and crospovidone polymers so that they may be considered for use in the treatment of hypertension for patients with drug-induced problems in tablet or capsule form.
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
Date 2019-11-14
Type info:eu-repo/semantics/article
Format application/pdf
Source Open Access Macedonian Journal of Medical Sciences; Vol. 7 No. 22 (2019): Nov 30 (Herbal Medicine in Pharmaceutical and Clinical Sciences); 3811-3815
Language eng
Rights Copyright (c) 2019 Sumaiyah Sumaiyah, Julia Mentari, Suryanto Suryanto (Author)

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