Protective effect of rotavirus immunization in acute diarrhea due to rotavirus infection: a prospective cohort study

Educativa

View Publication Info
 
 
Field Value
 
Title Protective effect of rotavirus immunization in acute diarrhea due to rotavirus infection: a prospective cohort study
 
Creator Indayani, Anak Agung Wiwin; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
Karyana, I Putu Gede; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
Utama, Made Gede Dwi Lingga; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
Sidiartha, I Gusti Lanang; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
Subanada, Ida Bagus; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
Widnyana, Anak Agung Ketut Putra; Gastro-hepatology Division, Department of Pediatrics, Faculty of Medicine Universitas Udayana
 
Subject Pediatrics
Diarrhea, Rotavirus, Immunization
 
Description Background: Diarrhea is a life-threatening disease for children. In Indonesia, the incidence of rotavirus infection was 67% of all cases of acute diarrhea. Immunization is an effort that can be done to prevent acute diarrhea due to rotavirus infection. Rotarix® vaccine is expected to have protective effect against acute diarrhea due to rotavirus infection. This study aims to investigate the protective effect of immunization against rotavirus on the incidence of acute diarrhea in children due to rotavirus infection.Methods: This was an analytical study using prospective cohort approach in private pediatric clinics in Denpasar, Bali, Indonesia. Participants include one-hundred children aged 6 months was divided into two groups, i.e. vaccinated and non-vaccinated groups, each consisting of 50 children. Incidence of acute diarrhea in both groups were measured and subsequent statistical analyses were conducted to determine contributing factors for the protective effect of rotavirus vaccine against acute diarrhea. Results: The incidence of rotavirus infection in vaccinated children was 6%, compared to 24% in the non-vaccinated children. There was significant association between vaccination status and the incidence of acute diarrhea due to rotavirus infection (p value=0.012). The probability of acute diarrhea due to rotavirus infection in both groups were 15% and 52% for the vaccinated and non-vaccinated groups, respectively. The relative risk reduction of acute diarrhea due to rotavirus infection is 71% [RR=0.288; 95% CI (52% -82%)].Conclusions: Immunization against rotavirus infection has a statistically significant protective effect against acute diarrhea due to rotavirus infection.
 
Publisher DiscoverSys Inc.
 
Contributor
 
Date 2019-12-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://www.balimedicaljournal.org/index.php/bmj/article/view/1586
10.15562/bmj.v8i3.1586
 
Source Bali Medical Journal; Vol 8, No 3 (2019): (Available online 1 December 2019); 934-939
2302-2914
2089-1180
 
Language eng
 
Relation https://www.balimedicaljournal.org/index.php/bmj/article/view/1586/pdf
 
Rights Copyright (c) 2019 Bali Medical Journal
http://creativecommons.org/licenses/by-nc-nd/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library