Phaleria macrocarpa Fruit Extract Inhibits NF-ĸB Activation and Apoptosis Induction on HeLa Cells

Indonesian Journal of Cancer Chemoprevention

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Field Value
 
Title Phaleria macrocarpa Fruit Extract Inhibits NF-ĸB Activation and Apoptosis Induction on HeLa Cells
 
Creator Zulharini S., Meirizky
Miranda, Amalia
Permatasari, Lina
Fadliyah, Hilyatul
Jenie, Riris Istighfari
 
Description NF-κB is a transcription factor and if activated, it induces apoptosis inhibition. Phalerin from Phaleria macrocarpa fruits expected to inhibit NF-κB activation. This research is to investigate anticancer mechanism of Phaleria macrocarpa fruits extracts (EBMD) in NF-κB pathway. Molecular docking assay was performed to determine phalerin affinity to IKK. Cytotoxic activity was observed by MTT assay. Double staining was performed to determine the apoptotic cells. Docking score of phalerin to IKK is -60. The IC50 value of EBMD is 629 μg/mL. Apoptosis profile shows (shown that) many cells undergoing apoptosis after treatment. Thus, EBMD potentially inhibits activation of NF-κB pathway and triggers apoptosis on HeLa cells.Keywords : NF-κB, Phaleria macrocarpa, sel HeLa, Bcl-2, IKK, molecular docking
 
Publisher Indonesian Society for Cancer Chemoprevention
 
Contributor
 
Date 2017-04-27
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://ijcc.chemoprev.org/index.php/ijcc/article/view/119
10.14499/indonesianjcanchemoprev8iss1pp9-14
 
Source Indonesian Journal of Cancer Chemoprevention; Vol 8, No 1 (2017); 9-14
2355-8989
2088-0197
 
Language eng
 
Relation https://ijcc.chemoprev.org/index.php/ijcc/article/view/119/114
 
Rights Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention
 

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