Phaleria macrocarpa Fruit Extract Inhibits NF-ĸB Activation and Apoptosis Induction on HeLa Cells

Indonesian Journal of Cancer Chemoprevention

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Title Phaleria macrocarpa Fruit Extract Inhibits NF-ĸB Activation and Apoptosis Induction on HeLa Cells
Creator Zulharini S., Meirizky
Miranda, Amalia
Permatasari, Lina
Fadliyah, Hilyatul
Jenie, Riris Istighfari
Description NF-κB is a transcription factor and if activated, it induces apoptosis inhibition. Phalerin from Phaleria macrocarpa fruits expected to inhibit NF-κB activation. This research is to investigate anticancer mechanism of Phaleria macrocarpa fruits extracts (EBMD) in NF-κB pathway. Molecular docking assay was performed to determine phalerin affinity to IKK. Cytotoxic activity was observed by MTT assay. Double staining was performed to determine the apoptotic cells. Docking score of phalerin to IKK is -60. The IC50 value of EBMD is 629 μg/mL. Apoptosis profile shows (shown that) many cells undergoing apoptosis after treatment. Thus, EBMD potentially inhibits activation of NF-κB pathway and triggers apoptosis on HeLa cells.Keywords : NF-κB, Phaleria macrocarpa, sel HeLa, Bcl-2, IKK, molecular docking
Publisher Indonesian Society for Cancer Chemoprevention
Date 2017-04-27
Type info:eu-repo/semantics/article

Format application/pdf
Source Indonesian Journal of Cancer Chemoprevention; Vol 8, No 1 (2017); 9-14
Language eng
Rights Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention

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