A study of plasma homocysteine levels in type 2 diabetes mellitus and its correlation with diabetic retinopathy

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Title A study of plasma homocysteine levels in type 2 diabetes mellitus and its correlation with diabetic retinopathy
 
Creator Bande, Uday S
Y, Chethan
 
Description Introduction: Diabetic Retinopathy is an ocular manifestation of diabetes, asystemic disease, which affects up to 80 percent of all patients who have had diabetes for 20 years or more. Homocysteine (Hcy) is a highly reactive Thiol-containing amino acid derived from the conversion of methionine to cysteine, producing reactive oxygen species – hydrogen peroxide and upper oxide anion radical. Findings may have implications for treatment of hyperhomocysteinemia to prevent   further vascular damage & micro complications in type 2 Diabetes Mellitus.
Aims and objectives: To find correlation between plasma homocysteine (tHcy) values and  Type 2 Diabetes with and without Retinopathy.
Materials and methods: It s a single centre Case control study. Three groups will be selected. In study group, 50 patients of newly detected diabetes mellitus or known case of diabetes mellitus will undergo fundoscopy and those with NPDR and PDR and normal RFT will be categorised in group 1. 50 patients of newly detected diabetes mellitus or known case of diabetes mellitus with normalfundoscopy, RFT are included in group 2 (selected by random sampling procedure). 50 Control group involving non diabetic individuals with normal renal parameters and No other medical conditions mentioned in exclusion criteria will be selected randomly and categorised in to group   plasma homocysteine levels of all the three groups are tabulated and compared.
Results: In DM group, mean Homocysteine was 14.90 ± 5.59, in DR group, mean Homocysteine was 38.86 ± 7.69 and in controls, mean Homocysteine was 10.61 ± 1.46. There was significant difference in mean plasma Homocysteine between three groups. (p value <0.001).
Conclusion: Mean (± SD) level of plasma homocysteine was higher among the DR group (NPDR) as compared to the DM group and controls, the difference was statistically significant.
 
Publisher Scholar Science Journals
 
Date 2019-08-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://ssjournals.com/index.php/ijbr/article/view/5221
10.7439/ijbr.v10i8.5221
 
Source International Journal of Biomedical Research; Vol 10 No 8 (2019): Aug; e5221
0976-9633
2455-0566
 
Language eng
 
Relation https://ssjournals.com/index.php/ijbr/article/view/5221/3552
 
Rights Copyright (c) 2019 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0
 

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