Evaluasi Keamanan dan Manfaat Ramuan Jamu untuk Hiperurisemia

Buletin Penelitian Kesehatan

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Field Value
 
Title Evaluasi Keamanan dan Manfaat Ramuan Jamu untuk Hiperurisemia
 
Creator Fitriani, Ulfa
Ardiyanto, Danang; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
Mana, Tofan Aries; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
 
Subject hiperurisemia, Jamu, keamanan, khasiat
 
Description AbstractHyperuricemia is a condition where there is an elevated blood uric acid level above normal range. Hyperuricemia occurs due to increased uric acid metabolism, decreased uric acid expenditure, or a combination of both. The Jamu formula containingPiper retrofractum, Plantago majorandApiumgraveolens have the potential to overcome hyperuricemia. This study aims to evaluate the safety and efficacy of formula inhuman subjects with hyperuricemia. The method used was pre and posttest design for 28 days. Safety parameters were assessed by renal function (urea and creatinine) and liver function (SGOT and SGPT). The parameters of efficacy were measured by uric acid change (H0, H14, and H28), improvement of clinical symptoms and quality of life (SF-36). This study showed that kidney and liver function still in the normal rangeafter28 days of intervention. The levels of uric acid showed a significant decrease (p <0.05). Clinical symptoms of the subjectsimproved after 17 daysofintervention. SF-36indicated significant improvement (p <0.05). It can be concluded that the formula was proved to be safe and effective for 28 daysof intervention.Key words: hyperuricemia, jamu, safety, efficacyAbstrakHiperurisemia adalah suatu keadaan dimana terjadi peningkatan kadar asam urat darah di atas rentang normal. Hiperurisemia terjadi karena adanya peningkatan metabolisme asam urat, penurunan pengeluaranasam urat, atau gabungan keduanya. Ramuan jamu yang terdiri dari buah cabe jawa (Piper retrofractum), daun sendok (Plantago major) dan herba seledri (Apium graveolens) berpotensi dalam mengatasi hiperurisemia. Penelitian ini bertujuan untuk melakukan evaluasi keamanan dan manfaat ramuan jamudengan subjek manusia dengan hiperurisemia. Metode yang digunakan adalah quasi eksperimental pre and post test design selama 28 hari dengan 50 subjek. Parameter keamanan dinilai berdasarkan fungsi ginjal (ureum dan kreatinin) dan fungsi hati (SGOT dan SGPT). Parameter manfaat dilihat dari perubahan asam urat subjek (H0, H14, H28), perbaikan gejala klinis dan pengukuran kualitas hidup (SF-36). Fungsi ginjal dan hati subjek setelah intervensi dalam rentang nilai normal. Kadar asam urat menunjukkan penurunan yang signifikan (p<0,05). Gejala klinis subjek membaik setelah intervensi selama 17 hari.Perubahan kualitas hidup subjek juga mengalami perbaikan yang signifikan (p<0,05). Dapat disimpulkan bahwa ramuan jamu terbukti aman dan bermanfaat dalam mengatasi hiperurisemia selama 28 hari.Kata kunci: Hiperurisemia, jamu, keamanan, khasiat
 
Publisher Badan Penelitian dan Pengembangan Kesehatan
 
Contributor Badan Penelitian Kesehatan Kementerian Kesehatan RI
 
Date 2017-12-30
 
Type
 
Format application/pdf
 
Identifier http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/view/6855
10.22435/bpk.v45i4.6855.227-232
 
Source Buletin Penelitian Kesehatan; Vol 45, No 4 (2017); 227-232
 
Language id
 
Relation http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6855/15601
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6855/15602
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6855/15603
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6855/15604
 
Rights The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
 

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