STUDI EFEK SAMPING OBAT PADA PASIEN NEONATUS YANG MENJALANI RAWAT INAP DI RUMAH SAKIT ANGKATAN LAUT DR. RAMELAN SURABAYA

Journal of Tropical Pharmacy and Chemistry

View Publication Info
 
 
Field Value
 
Title STUDI EFEK SAMPING OBAT PADA PASIEN NEONATUS YANG MENJALANI RAWAT INAP DI RUMAH SAKIT ANGKATAN LAUT DR. RAMELAN SURABAYA
 
Creator Fitriani, Victoria Yulita
Widyati, Widyati
Huibeis, Azis
Wisanti, Retno
 
Description ABSTRACT
 
Rational drug treatments to avoid adverse drug reactions in neonates are depend on physiologic immaturity and age-related changes in pharmacokinetic and pharmacodynamic factor. This condition lead neonates more prone to adverse drug reaction than adults.The aim of this study was to estimate the prevalence of adverse drug reactions that occured at Dr. Ramelan Navy Hospital's NICU observed in November 26th 2007 to January 26th 2008. It was also to analyze kind of medication that caused adverse drug reactions.The study employed 94 patients (5 premature neonates and 89 term neonates) who were observed perspectively from November 26th 2007 to January 26th 2008. Demographic data, drug therapy, relevant medical histories, laboratory data were recorded in this study. The study result was assessed by literature study. The study result were analysed with Descriptive analysis. The most common adverse drug reaction occurred in this population was potential adverse drug reaction (99.5%). The most adverse drug reaction generated from this study was come from the use of ampicillin sulbactam (42.7%), gentamisin (31.4%), ceftriaxone (16.2 %), amikacin (7.6 %), aminofilin (1.1 %), ampicillin (0.5 %), and dexamethasone (0.5 %). The study showed that almost all of adverse drug reaction occurred in this study was potential adverse drug reaction (99.5%).
 
Keywords: neonates; adverse drug reactions; NICU
 
ABSTRAK
 
Terapi obat yang rasional untuk menghindari efek samping dari obat pada neonatus bergantung pada ketidakmatangan fisiologik dan perubahan faktor farmakokinetika dan farmakodinamika yang terkait usia. Kondisi ini membawa neonatus lebih mudah terpapar efek samping obat daripada orang dewasa. Tujuan dari penelitian ini adalah untuk memperkirakan angka kejadian efek samping obat yang terjadi di NICU Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini juga menganalisa jenis obat yang menyebabkan efek samping obat. Penelitian ini melibatkan 94 pasien (5 neonatus premature dan 89 neonatus term) yang diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini mencatat data demografi, terapi obat, sejarah penyakit yang terkait, dan data laboratorium. Data tersebut dianalisa melalui studi literatur. Hasil penelitian dianalisa dengan menggunakan analisis deskriptif. Efek samping obat yang sering muncul pada penelitian ini adalah efek samping potensial (99.5%). Efek samping yang terjadi pada penelitian ini terjadi akibat penggunaan ampisilin sulbaktam (42.7%), gentamisin (31.4%), ceftriaxon (16.2%), amikasin (7.6%), aminofilin (1.1%), ampisilin (0.5%), dan deksametason (0.5%). Penelitian ini menunjukkan bahwa sebagian besar efek samping obat yang terjadi pada penelitian ini adalah efek samping obat potensial.
 
Kata kunci: neonatus; efek samping obat; NICU
 
Publisher Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117
 
Date 2010-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/11
10.25026/jtpc.v1i1.11
 
Source Journal of Tropical Pharmacy and Chemistry; Vol 1 No 1 (2010)
2407-6090
2087-7099
 
Language eng
 
Relation https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/11/13
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library